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- W2080780019 abstract "The utricle and saccule contain hair cells, which are the peripheral sensors of change in gravity that transmit signals regarding these changes to the neural components of the vestibular system. Although the fundamental neural pathways, especially the vestibular reflex pathways, have been investigated extensively, the principals underlying the functional development of this system are under study at present. The objective of this review is to identify the gravity-sensing components of the vestibular system and to present an overview of the research performed on their development. The second part of this review is focused on one important aspect of development, the emergence of electrical excitability using the chick tangential vestibular nucleus as a model. The importance of this research to understanding vestibular compensation and vestibular disturbance during spaceflight is considered. Because there is a conservation of the fundamental pathways and function in vertebrate phylogeny from birds through mammals, findings from studies on avians should contribute significantly to understanding the mechanisms operating in mammals. Also, we expect that as the events and basic mechanisms underlying normal vestibular development are revealed, these will provide practical tools to investigate the pattern of recovery from dysfunction of the vestibular system. This is related to the evidence suggesting that recovery of function in different systems and cell lines, including neurons, involves repeating certain patterns established during development." @default.
- W2080780019 created "2016-06-24" @default.
- W2080780019 creator A5020596818 @default.
- W2080780019 date "2001-01-01" @default.
- W2080780019 modified "2023-10-16" @default.
- W2080780019 title "Development of the gravity sensing system" @default.
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- W2080780019 doi "https://doi.org/10.1002/1097-4547(20010115)63:2<103::aid-jnr1001>3.0.co;2-s" @default.
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