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- W2080784424 abstract "Stimulation of [3H]-arachidonic acid labeled human synovial cells with 3.0×10−10M recombinant interleukin-1 or tumor necrosis factor resulted in the release of incorporated radiolabel (41.1% and 27.7% respectively). Analysis of [3H]-arachidonic acid labeled phospholipids showed that interleukin-1 and tumor necrosis factor diminished [3H]-arachidonic acid in phosphatidylcholine phosphatidylserine and phosphatidylinositol. Treatment of [3H]-arachidonic acid labeled cells with 10−3M dibutyryl cyclic AMP or 10−6M PGE2 did not affect spontaneous or stimulated [3H] arachidonic acid release significantly. These data show that recombinant interleukin-1 and tumor necrosis factor stimulate human synovial cell phospholipase activity in a similar manner and that this activity is not affected significantly by agents that elevate cyclic AMP." @default.
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- W2080784424 date "1987-01-01" @default.
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- W2080784424 title "Recombinant tumor necrosis factor and intepleukin-1 both stimulate human synovial cell arachidonic acid release and phospholipid metabolism" @default.
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- W2080784424 doi "https://doi.org/10.1016/0006-291x(87)90476-1" @default.
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