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• W2080788086 abstract "Figure 1. This is patient BH’s 3-lead ECG that was published in the original article. The original caption should read right bundle branch block as the authors explained in their text. One of the most significant articles in the history of cardiology was published in 1930 under the rather unassuming title, Bundle-branch block with short P-R interval in healthy young people prone to paroxysmal tachycardia. The authors, whose names would be joined to form a wellknown eponym, were Louis Wolff of Boston, John Parkinson of London, and Paul Dudley White of Boston. White was very interested in the long-term follow-up of patients that he had seen during his half-century career. In his 1967 book on the long-term follow-up of patients with various types of cardiovascular disease, White reported on 2 of the 11 patients that he and his coauthors had described in their original Wollf-Parkinson-White article. White explained that 1 of those patients was a physician who was in good health 36 years after the report was published. As a result of a chance encounter, I discovered that 1 of Wolff, Parkinson, and White’s original 11 patients was alive and well until he developed heart failure and died at the age of 83, >7 decades after they summarized his case in their classic article. BH was 11 years old when he was seen by Dr. (later Sir) John Parkinson at the London Hospital on April 13, 1929. The boy had a history of exhaustion, occasional pallor, and a varying pulse rate that was often slow. For a year he had had recurrent attacks lasting a few days at a time in which he was pale with a pulse rate of 40 to 65 beats/min. His blood pressure, cardiac examination, and orthodiagram (a special type of chest x-ray) were normal. The boy’s electrocardiogram (ECG) showed a short PR interval of <0.1 second and what the authors described as left bundle branch block (Figure 1). I learned about the patient’s subsequent history from his son and from a 1953 article that reported 5 patients with pheochromocytoma, 1 of whom was BH. The episodes that Parkinson had described in the 1930 report subsided. But 12 years later, when BH was aged 23 years, he began having “attacks of epigastric discomfort, followed by slow forceful palpitation, and sometimes throbbing headache, nausea, vomiting, and dyspnea.” The authors of the pheochromocytoma report noted that his spells were also accompanied by sweating, shivering, and “slight” bradycardia. His blood pressure rose during them; the highest reading was 254/ 154 mm Hg. Between the attacks, his blood pressure varied from 120/86 mm Hg to 170/110 mm Hg. In 1949, when BH was 31 years old, he was diagnosed as having a pheochromocytoma. He was operated on at St Mary’s Hospital in London, and a very large tumor weighing 200 g was removed. Three years after surgery, the man was symptom free and a single blood pressure of 135/ 80 mm Hg was recorded. The authors did not mention an" @default.
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• W2080788086 date "2014-05-01" @default.
• W2080788086 modified "2023-09-24" @default.
• W2080788086 title "The Wolff-Parkinson-White Syndrome: A Very Long Follow-Up" @default.
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• W2080788086 doi "https://doi.org/10.1016/j.amjcard.2014.04.001" @default.
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