Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080794316> ?p ?o ?g. }
- W2080794316 endingPage "107" @default.
- W2080794316 startingPage "97" @default.
- W2080794316 abstract "A key hurdle for the further development of RNA interference (RNAi) therapeutics like small interfering RNA (siRNA) is their safe and effective delivery. Lipids are promising and versatile carriers because they are based on Nature's own building blocks and can be provided with properties which allow for protection of the siRNA, steric stabilization, targeting, membrane fusion and triggered drug release. At present a variety of lipid-based transfectants for siRNA delivery have been used for in vitro and in vivo purposes. The majority bears a cationic charge to electrostatically complex the siRNA into more hydrophobic lipoplexes, which promote passage of the siRNA across cellular membrane barriers, especially when lipids are added that facilitate membrane fusion. Despite these attractive features, siRNA delivery vehicles are facing a number of challenges such as the limited delivery efficiency in vivo, toxicity and non-specific stimulation of the immune system. To optimally design and tailor the lipidic systems for siRNA delivery, better insight is needed into the mechanisms of cell delivery. More specifically, further clarification is need regarding the nature of cell surface interactions, routes of internalization, passage of intracellular membranes, and mechanisms of immune activation. This review provides an overview of the main constituents currently employed in lipid-based siRNA carriers, and recent research into improvements of cell delivery. In addition, pitfalls related to immune activation and side effects are discussed, and possible ways to overcome them are highlighted." @default.
- W2080794316 created "2016-06-24" @default.
- W2080794316 creator A5042180788 @default.
- W2080794316 date "2012-01-01" @default.
- W2080794316 modified "2023-09-26" @default.
- W2080794316 title "siRNA Delivery with Lipid-based Systems: Promises and Pitfalls" @default.
- W2080794316 cites W1507317639 @default.
- W2080794316 cites W1515466910 @default.
- W2080794316 cites W1535643053 @default.
- W2080794316 cites W1579604458 @default.
- W2080794316 cites W1611419331 @default.
- W2080794316 cites W1647075334 @default.
- W2080794316 cites W1774527113 @default.
- W2080794316 cites W1934712179 @default.
- W2080794316 cites W1951507118 @default.
- W2080794316 cites W1964146045 @default.
- W2080794316 cites W1966334833 @default.
- W2080794316 cites W1968829868 @default.
- W2080794316 cites W1970546334 @default.
- W2080794316 cites W1971290197 @default.
- W2080794316 cites W1971933964 @default.
- W2080794316 cites W1971983208 @default.
- W2080794316 cites W19722338 @default.
- W2080794316 cites W1973285493 @default.
- W2080794316 cites W1975499385 @default.
- W2080794316 cites W1975833492 @default.
- W2080794316 cites W1976811878 @default.
- W2080794316 cites W1978705407 @default.
- W2080794316 cites W1979993551 @default.
- W2080794316 cites W1981057166 @default.
- W2080794316 cites W1983175508 @default.
- W2080794316 cites W1984085632 @default.
- W2080794316 cites W1984844589 @default.
- W2080794316 cites W1986078859 @default.
- W2080794316 cites W1989065176 @default.
- W2080794316 cites W1989611595 @default.
- W2080794316 cites W1989753758 @default.
- W2080794316 cites W1991533053 @default.
- W2080794316 cites W1992517046 @default.
- W2080794316 cites W2000742881 @default.
- W2080794316 cites W2001019246 @default.
- W2080794316 cites W2008718396 @default.
- W2080794316 cites W2009447610 @default.
- W2080794316 cites W2016035737 @default.
- W2080794316 cites W2017515700 @default.
- W2080794316 cites W2019387053 @default.
- W2080794316 cites W2019631541 @default.
- W2080794316 cites W2020368715 @default.
- W2080794316 cites W2021218243 @default.
- W2080794316 cites W2024256121 @default.
- W2080794316 cites W2025980739 @default.
- W2080794316 cites W2029827106 @default.
- W2080794316 cites W2031432800 @default.
- W2080794316 cites W2032234735 @default.
- W2080794316 cites W2032552096 @default.
- W2080794316 cites W2034342858 @default.
- W2080794316 cites W2035970470 @default.
- W2080794316 cites W2038660811 @default.
- W2080794316 cites W2046763396 @default.
- W2080794316 cites W2047124519 @default.
- W2080794316 cites W2047165821 @default.
- W2080794316 cites W2047904142 @default.
- W2080794316 cites W2057673475 @default.
- W2080794316 cites W2058253654 @default.
- W2080794316 cites W2058548073 @default.
- W2080794316 cites W2059355578 @default.
- W2080794316 cites W2060221489 @default.
- W2080794316 cites W2063107058 @default.
- W2080794316 cites W2063676577 @default.
- W2080794316 cites W2065068060 @default.
- W2080794316 cites W2065135000 @default.
- W2080794316 cites W2066606615 @default.
- W2080794316 cites W2068858471 @default.
- W2080794316 cites W2068953057 @default.
- W2080794316 cites W2071670416 @default.
- W2080794316 cites W2073156450 @default.
- W2080794316 cites W2074502352 @default.
- W2080794316 cites W2075300550 @default.
- W2080794316 cites W2078775246 @default.
- W2080794316 cites W2080323656 @default.
- W2080794316 cites W2082192685 @default.
- W2080794316 cites W2085217622 @default.
- W2080794316 cites W2086274688 @default.
- W2080794316 cites W2086778040 @default.
- W2080794316 cites W2086919915 @default.
- W2080794316 cites W2088119617 @default.
- W2080794316 cites W2088650511 @default.
- W2080794316 cites W2091878182 @default.
- W2080794316 cites W2092770422 @default.
- W2080794316 cites W2093821510 @default.
- W2080794316 cites W2095151181 @default.
- W2080794316 cites W2098351459 @default.
- W2080794316 cites W2100808905 @default.
- W2080794316 cites W2101543035 @default.
- W2080794316 cites W2105364677 @default.
- W2080794316 cites W2105666528 @default.
- W2080794316 cites W2106601257 @default.
- W2080794316 cites W2108607299 @default.