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• W2080795893 abstract "Human cytomegalovirus (CMV) infection has been linked to inflammatory diseases, including vascular disease and chronic transplant rejection, that involve vascular endothelial damage. We have previously shown that the host CD4+ T-cell response to CMV antigen can produce IFNγ and TNFα at levels sufficient to drive induction of fractalkine, a key marker of inflammation in endothelial cells. We have also observed a major pathogenic effect in which endothelial cell damage and loss follow the induction of frac-talkine and up-regulation of cell adhesion markers in the presence of peripheral blood mononuclear cells (PBMCs) from donors with a high CMV-specific T-cell frequency. In this report, we show that the fractalkine-CX3CR1 interaction resulting in recruitment of natural killer (NK) cells and monocyte-macrophages plays an important role in mediating this endothelial damage. Supportive evidence for frac-talkine's key role is shown by the ability of specific antibody to CX3CR1 to reduce significantly CX3CR1+-bearing cell chemoattraction and to protect against endothelial damage. These findings support CMV as a member of a class of persistent pathogens in which a high T-cell response and chemokine-mediated effects are a risk factor for development of chronic inflammation and endothelial cell injury." @default.
• W2080795893 created "2016-06-24" @default.
• W2080795893 creator A5017306542 @default.
• W2080795893 creator A5055150149 @default.
• W2080795893 date "2008-01-01" @default.
• W2080795893 modified "2023-10-11" @default.
• W2080795893 title "Endothelial damage from cytomegalovirus-specific host immune response can be prevented by targeted disruption of fractalkine-CX3CR1 interaction" @default.
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• W2080795893 doi "https://doi.org/10.1182/blood-2007-08-107730" @default.
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