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• W2080796003 abstract "Abstract Aim: Tissue plasminogen activator (t‐PA) and plasminogen activator inhibitor‐1 (PAI‐1) have important roles in proteolytic events in periodontitis. The aim of this study was to investigate TPA and PAI‐1 gene polymorphisms in relation to susceptibility to generalized aggressive periodontitis (G‐AgP). Methods: Genomic DNA was obtained from peripheral blood of 90 G‐AgP patients and 154 periodontally healthy subjects. 4G/5G polymorphism in the promoter region of the PAI‐1 gene and Alu‐repeat insertion/deletion (I/D) polymorphism in intron 8 of the TPA gene were genotyped by polymerase chain reaction and endonuclease digestion. Results: The genotype distributions of TPA and PAI‐1 genes were similar between G‐AgP and healthy subjects ( p >0.05). The distribution of TPA genotypes in G‐AgP patients was 33.4% D/D, 44.4% I/D, and 22.2% I/I and was 26.3% D/D, 40.4% I/D, and 33.3% I/I in healthy subjects. The D allele was 55.6% in G‐AgP and 46.6% in healthy subjects. There was a significant difference among study groups in D allele frequencies ( p =0.044). The PAI‐1 genotype distribution in G‐AgP was 29.1% 4G/4G, 43.0% 4G/5G, and 27.9% 5G/5G, while it was 35.7% 4G/4G, 43.8% 4G/5G, and 20.5% 5G/5G in healthy subjects. Conclusion: These data suggest that the D polymorphic allele of TPA gene polymorphism could be associated with susceptibility to G‐AgP in Turkish subjects." @default.
• W2080796003 created "2016-06-24" @default.
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• W2080796003 date "2007-03-16" @default.
• W2080796003 modified "2023-10-16" @default.
• W2080796003 title "Gene polymorphisms of tissue plasminogen activator and plasminogen activator inhibitor-1 in Turkish patients with generalized aggressive periodontitis" @default.
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• W2080796003 doi "https://doi.org/10.1111/j.1600-051x.2007.01049.x" @default.
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