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• W2080798045 abstract "Increasing azithromycin treatment failure in sexually transmitted Mycoplasma genitalium infection, is linked to macrolide resistance and second-line treatment relies on the fluoroquinolone, moxifloxacin. We recently detected fluoroquinolone and macrolide resistance-associated mutations in 15% and 43%, respectively, of 143 initial M. genitalium PCR-positive specimens. For a subset of 33 Western Sydney Sexual Health Centre patients, clinical information and results of sequence analysis of M. genitalium macrolide and fluoroquinolone target genes – the 23S rRNA gene, and parC and gyrA, respectively – were used to examine whether mutations were associated with treatment failure. Macrolide resistance-associated mutations correlated with microbiological ( p = 0.013) and clinical ( p = 0.024) treatment failure, and fluoroquinolone resistance-associated mutations with microbiological moxifloxacin treatment failure ( p = 0.005). We describe the first reported cases of clinical and microbiological moxifloxacin treatment failure. Failure of first- and second-line antibiotic treatment of M. genitalium infection is occurring and likely to increase with current treatment strategies." @default.
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• W2080798045 date "2013-08-29" @default.
• W2080798045 modified "2023-09-26" @default.
• W2080798045 title "Failure of moxifloxacin treatment in <i>Mycoplasma genitalium</i> infections due to macrolide and fluoroquinolone resistance" @default.
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• W2080798045 doi "https://doi.org/10.1177/0956462413502008" @default.
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