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- W2080798807 abstract "Over the past few years a great deal of research has examined how T cell-dependent immune responses are initiated and subsequently regulated. Ligation of the TCR with an antigenic peptide bound to an MHC protein on a professional APC provides the crucial antigen-specific stimulus required for T cell activation. Interaction of CD28 with CD80 or CD86 molecules on APC initiates a costimulatory or second signal within the T cell which augments and sustains T cell activation initiated through the TCR. However, recently it has become clear that T cell immune responses are a result of a balance between stimulatory and inhibitory signals. Cytotoxic T lymphocyte-associated molecule-4 (CTLA-4) is a cell surface molecule that is expressed nearly exclusively on CD4+ and CD8+ T cells. Investigation into the role of CTLA-4 in the regulation of T cell immune responses has revealed that CTLA-4 is a very important molecule involved in the maintenance of T cell homeostasis. In the present review, evidence for the proposed inhibitory role of CTLA-4 is examined and a model suggesting a role for CTLA-4 in both early and late stages of T cell activation is presented." @default.
- W2080798807 created "2016-06-24" @default.
- W2080798807 creator A5002125155 @default.
- W2080798807 creator A5039795688 @default.
- W2080798807 date "1999-02-01" @default.
- W2080798807 modified "2023-10-13" @default.
- W2080798807 title "The role of CTLA-4 in the regulation of T cell immune responses" @default.
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- W2080798807 doi "https://doi.org/10.1046/j.1440-1711.1999.00795.x" @default.
- W2080798807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10101680" @default.
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