Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080800518> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2080800518 endingPage "261" @default.
- W2080800518 startingPage "254" @default.
- W2080800518 abstract "Although mitochondrial μ- and m-calpains play significant roles in apoptotic cell death, their activating mechanisms have not been determined. The purpose of this study was to determine the core factors that are involved in activating mitochondrial outer membrane (OM)-bound calpains. To accomplish this, we solubilized OM-bound calpains and separated them by DEAE-Sepharose column chromatography, and identified them by immunoblots. We also determined the core factors that activated the OM-bound calpains and release them from the OM by calpain assays, immunoprecipitations, and immunoblots. The OM-bound m-calpain large subunit was not associated with the small subunit or with Grp75 chaperone. Free calpain small subunit was located in the IMS and caused the release of the OM-bound m-calpain large subunit from the OM together with Grp75, ATP, and Ca2+. Our results showed that the activating mechanism of mitochondrial OM-bound m-calpain and the release of mitochondrial m-calpain from the OM have important implications in facilitating apoptotic cell death." @default.
- W2080800518 created "2016-06-24" @default.
- W2080800518 creator A5000738181 @default.
- W2080800518 creator A5062898164 @default.
- W2080800518 creator A5063134169 @default.
- W2080800518 date "2011-03-01" @default.
- W2080800518 modified "2023-09-26" @default.
- W2080800518 title "Ca2+-induced release of mitochondrial m-calpain from outer membrane with binding of calpain small subunit and Grp75" @default.
- W2080800518 cites W1523373796 @default.
- W2080800518 cites W1558232630 @default.
- W2080800518 cites W1970884186 @default.
- W2080800518 cites W1992198404 @default.
- W2080800518 cites W1992565982 @default.
- W2080800518 cites W2007354490 @default.
- W2080800518 cites W2012070550 @default.
- W2080800518 cites W2032089911 @default.
- W2080800518 cites W2073193446 @default.
- W2080800518 cites W2087959061 @default.
- W2080800518 cites W2090057285 @default.
- W2080800518 cites W2092851271 @default.
- W2080800518 cites W2111972716 @default.
- W2080800518 cites W2113355106 @default.
- W2080800518 cites W2151078743 @default.
- W2080800518 cites W2151359759 @default.
- W2080800518 cites W2169436026 @default.
- W2080800518 cites W2178185732 @default.
- W2080800518 cites W4293247451 @default.
- W2080800518 doi "https://doi.org/10.1016/j.abb.2010.12.003" @default.
- W2080800518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21145877" @default.
- W2080800518 hasPublicationYear "2011" @default.
- W2080800518 type Work @default.
- W2080800518 sameAs 2080800518 @default.
- W2080800518 citedByCount "14" @default.
- W2080800518 countsByYear W20808005182012 @default.
- W2080800518 countsByYear W20808005182013 @default.
- W2080800518 countsByYear W20808005182015 @default.
- W2080800518 countsByYear W20808005182016 @default.
- W2080800518 countsByYear W20808005182017 @default.
- W2080800518 countsByYear W20808005182018 @default.
- W2080800518 countsByYear W20808005182022 @default.
- W2080800518 crossrefType "journal-article" @default.
- W2080800518 hasAuthorship W2080800518A5000738181 @default.
- W2080800518 hasAuthorship W2080800518A5062898164 @default.
- W2080800518 hasAuthorship W2080800518A5063134169 @default.
- W2080800518 hasConcept C104292427 @default.
- W2080800518 hasConcept C104317684 @default.
- W2080800518 hasConcept C153911025 @default.
- W2080800518 hasConcept C181199279 @default.
- W2080800518 hasConcept C185592680 @default.
- W2080800518 hasConcept C190283241 @default.
- W2080800518 hasConcept C28859421 @default.
- W2080800518 hasConcept C31573885 @default.
- W2080800518 hasConcept C55493867 @default.
- W2080800518 hasConcept C56928146 @default.
- W2080800518 hasConcept C75385678 @default.
- W2080800518 hasConcept C86803240 @default.
- W2080800518 hasConcept C95444343 @default.
- W2080800518 hasConcept C98539663 @default.
- W2080800518 hasConceptScore W2080800518C104292427 @default.
- W2080800518 hasConceptScore W2080800518C104317684 @default.
- W2080800518 hasConceptScore W2080800518C153911025 @default.
- W2080800518 hasConceptScore W2080800518C181199279 @default.
- W2080800518 hasConceptScore W2080800518C185592680 @default.
- W2080800518 hasConceptScore W2080800518C190283241 @default.
- W2080800518 hasConceptScore W2080800518C28859421 @default.
- W2080800518 hasConceptScore W2080800518C31573885 @default.
- W2080800518 hasConceptScore W2080800518C55493867 @default.
- W2080800518 hasConceptScore W2080800518C56928146 @default.
- W2080800518 hasConceptScore W2080800518C75385678 @default.
- W2080800518 hasConceptScore W2080800518C86803240 @default.
- W2080800518 hasConceptScore W2080800518C95444343 @default.
- W2080800518 hasConceptScore W2080800518C98539663 @default.
- W2080800518 hasIssue "2" @default.
- W2080800518 hasLocation W20808005181 @default.
- W2080800518 hasLocation W20808005182 @default.
- W2080800518 hasOpenAccess W2080800518 @default.
- W2080800518 hasPrimaryLocation W20808005181 @default.
- W2080800518 hasRelatedWork W1528360579 @default.
- W2080800518 hasRelatedWork W1567321500 @default.
- W2080800518 hasRelatedWork W1967012492 @default.
- W2080800518 hasRelatedWork W2036667953 @default.
- W2080800518 hasRelatedWork W2092960967 @default.
- W2080800518 hasRelatedWork W2383263084 @default.
- W2080800518 hasRelatedWork W2387025442 @default.
- W2080800518 hasRelatedWork W2795309116 @default.
- W2080800518 hasRelatedWork W3046665064 @default.
- W2080800518 hasRelatedWork W4309721421 @default.
- W2080800518 hasVolume "507" @default.
- W2080800518 isParatext "false" @default.
- W2080800518 isRetracted "false" @default.
- W2080800518 magId "2080800518" @default.
- W2080800518 workType "article" @default.