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• W2080801663 abstract "Substance P (SP), physalaemin, SP4-11, SP5-11 and the SP5-11 analog DiMe-C7 induce an antinociceptive effect in rats after intraventricular administration. Other tachykinins and the N-terminal fragments of SP are inactive. All antinociceptive peptides increase the Met-enkephalin efflux from slices of rat periaqueductal gray matter and their antinociceptive potency is correlated with their capacity to release Met-enkephalin. The results, discussed in the light of current theories on different tachykinin receptors, suggest that the SP-P receptor subtype may be involved in the control of noxious stimulation elicited by SP at supraspinal levels." @default.
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• W2080801663 date "1986-05-01" @default.
• W2080801663 modified "2023-10-15" @default.
• W2080801663 title "Antinociceptive and Met-enkephalin releasing effects of tachykinins and substance P fragments" @default.
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• W2080801663 doi "https://doi.org/10.1016/0196-9781(86)90008-2" @default.
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