Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080802180> ?p ?o ?g. }
- W2080802180 endingPage "64" @default.
- W2080802180 startingPage "51" @default.
- W2080802180 abstract "Nuclear import of macromolecules or particles is a strictly regulated phenomenon that is now understood in some depth at the molecular level. Transport across nuclear membranes is controlled by nuclear pores, with the involvement of cytoplasmic receptors and accessory molecules. Each nuclear pore complex is an assembly of multiple copies of at least 30 distinct proteins, with a total mass of approximately 10(7) kDa. Passive transport of small molecules through nuclear pores is unrestricted, but efficient uptake of macromolecules requires nuclear localization signals, which facilitate the interaction with cytoplasmic receptor proteins. The basic architecture of the nuclear pore and the mechanisms that regulate nuclear import are summarized, in relation to import of endogenous molecules and viruses. Subsequently, the significance of these mechanisms in controlling gene delivery is discussed. Access of DNA to the nucleus is a major barrier to the success of gene therapy, although viruses have evolved mechanisms to exploit the active transport machinery within the host cell. A key step in the future development of non-viral gene therapy will be the design and development of synthetic systems for active delivery of DNA to the nucleus." @default.
- W2080802180 created "2016-06-24" @default.
- W2080802180 creator A5037277601 @default.
- W2080802180 date "1998-10-01" @default.
- W2080802180 modified "2023-10-14" @default.
- W2080802180 title "Nuclear import of polypeptides, polynucleotides and supramolecular complexes" @default.
- W2080802180 cites W100005266 @default.
- W2080802180 cites W1555717670 @default.
- W2080802180 cites W1575983052 @default.
- W2080802180 cites W1607616388 @default.
- W2080802180 cites W1801052842 @default.
- W2080802180 cites W1837201208 @default.
- W2080802180 cites W188209071 @default.
- W2080802180 cites W1902070349 @default.
- W2080802180 cites W1951130496 @default.
- W2080802180 cites W1966947732 @default.
- W2080802180 cites W1967225591 @default.
- W2080802180 cites W1968098538 @default.
- W2080802180 cites W1968191899 @default.
- W2080802180 cites W1968458490 @default.
- W2080802180 cites W1969081197 @default.
- W2080802180 cites W1969918693 @default.
- W2080802180 cites W1971300341 @default.
- W2080802180 cites W1973731625 @default.
- W2080802180 cites W1983647029 @default.
- W2080802180 cites W1984371849 @default.
- W2080802180 cites W1984454232 @default.
- W2080802180 cites W1991153512 @default.
- W2080802180 cites W1992155709 @default.
- W2080802180 cites W2003833710 @default.
- W2080802180 cites W2009207470 @default.
- W2080802180 cites W2014495927 @default.
- W2080802180 cites W2023842478 @default.
- W2080802180 cites W2026532992 @default.
- W2080802180 cites W2027641598 @default.
- W2080802180 cites W2027980197 @default.
- W2080802180 cites W2031766817 @default.
- W2080802180 cites W2033457980 @default.
- W2080802180 cites W2033722975 @default.
- W2080802180 cites W2033906494 @default.
- W2080802180 cites W2037928479 @default.
- W2080802180 cites W2046318163 @default.
- W2080802180 cites W2046617996 @default.
- W2080802180 cites W2047454655 @default.
- W2080802180 cites W2053796273 @default.
- W2080802180 cites W2055574063 @default.
- W2080802180 cites W2058855160 @default.
- W2080802180 cites W2060088582 @default.
- W2080802180 cites W2061555550 @default.
- W2080802180 cites W2065235814 @default.
- W2080802180 cites W2068350301 @default.
- W2080802180 cites W2068370931 @default.
- W2080802180 cites W2070831615 @default.
- W2080802180 cites W2071957053 @default.
- W2080802180 cites W2076500970 @default.
- W2080802180 cites W2081460974 @default.
- W2080802180 cites W2083392791 @default.
- W2080802180 cites W2086274688 @default.
- W2080802180 cites W2087302056 @default.
- W2080802180 cites W2093159000 @default.
- W2080802180 cites W2097239500 @default.
- W2080802180 cites W2105896882 @default.
- W2080802180 cites W2142261712 @default.
- W2080802180 cites W2143566830 @default.
- W2080802180 cites W2158125183 @default.
- W2080802180 cites W2158374311 @default.
- W2080802180 cites W2159090199 @default.
- W2080802180 cites W2409889381 @default.
- W2080802180 cites W270470139 @default.
- W2080802180 cites W2804367574 @default.
- W2080802180 cites W3094428041 @default.
- W2080802180 cites W39288136 @default.
- W2080802180 cites W4211020343 @default.
- W2080802180 cites W748860 @default.
- W2080802180 cites W90652655 @default.
- W2080802180 doi "https://doi.org/10.1016/s0169-409x(98)00050-7" @default.
- W2080802180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10837670" @default.
- W2080802180 hasPublicationYear "1998" @default.
- W2080802180 type Work @default.
- W2080802180 sameAs 2080802180 @default.
- W2080802180 citedByCount "57" @default.
- W2080802180 countsByYear W20808021802012 @default.
- W2080802180 countsByYear W20808021802014 @default.
- W2080802180 countsByYear W20808021802015 @default.
- W2080802180 countsByYear W20808021802017 @default.
- W2080802180 countsByYear W20808021802021 @default.
- W2080802180 crossrefType "journal-article" @default.
- W2080802180 hasAuthorship W2080802180A5037277601 @default.
- W2080802180 hasConcept C104317684 @default.
- W2080802180 hasConcept C111921641 @default.
- W2080802180 hasConcept C12554922 @default.
- W2080802180 hasConcept C126725582 @default.
- W2080802180 hasConcept C185592680 @default.
- W2080802180 hasConcept C190062978 @default.
- W2080802180 hasConcept C204389451 @default.
- W2080802180 hasConcept C2777896290 @default.
- W2080802180 hasConcept C2780114586 @default.
- W2080802180 hasConcept C2780723820 @default.