Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080805039> ?p ?o ?g. }
- W2080805039 endingPage "50" @default.
- W2080805039 startingPage "44" @default.
- W2080805039 abstract "During human pregnancy, progesterone induced decidual cells protect against hemorrhage: 1) as endovascular trophoblast breech and remodel uterine blood vessels; and 2) in the third stage of labor following preterm and term delivery. De- cidual cells promote hemostasis through enhanced expression of tissue factor (TF), the primary initiator of hemostasis via thrombin generation, and plasminogen activator inhibitor-1, which inactivates tissue type plasminogen activator, the primary fibrinolytic agent. Abruptions (decidual hemorrhage) produce excess thrombin which acts as autocrine/paracrine inducer of decidual cell expressed matrix metalloproteinases and of neutrophil chemoattractant and activator, interleukin-8. The latter mediates aseptic abruption-related neutrophil infiltration. During abruptions, decidual cell and neutrophil-derived proteases effectively degrade the decidual and fetal membrane extracellular matrix to promote preterm premature rupture of the membranes and preterm delivery (PTD). Decidual cell-derived thrombin weakens the amniotic membrane and lowers decidual cell-expressed progesterone receptor levels by increasing phospho-ERK1/2 signaling. The resulting functional progesterone withdrawal accompanies PTD." @default.
- W2080805039 created "2016-06-24" @default.
- W2080805039 creator A5005680652 @default.
- W2080805039 creator A5011014484 @default.
- W2080805039 creator A5027040780 @default.
- W2080805039 creator A5028701315 @default.
- W2080805039 creator A5036108835 @default.
- W2080805039 creator A5056713141 @default.
- W2080805039 creator A5069212517 @default.
- W2080805039 creator A5073129043 @default.
- W2080805039 creator A5074006991 @default.
- W2080805039 creator A5086200879 @default.
- W2080805039 date "2013-01-01" @default.
- W2080805039 modified "2023-10-16" @default.
- W2080805039 title "Decidual cell expressed tissue factor promotes endometrial hemostasis while mediating abruption associated preterm birth" @default.
- W2080805039 cites W1966179309 @default.
- W2080805039 cites W1975195151 @default.
- W2080805039 cites W1982254799 @default.
- W2080805039 cites W1988892839 @default.
- W2080805039 cites W1997802835 @default.
- W2080805039 cites W1998238635 @default.
- W2080805039 cites W2002771508 @default.
- W2080805039 cites W2009761852 @default.
- W2080805039 cites W2027078534 @default.
- W2080805039 cites W2034149357 @default.
- W2080805039 cites W2034492080 @default.
- W2080805039 cites W2038750685 @default.
- W2080805039 cites W2041003067 @default.
- W2080805039 cites W2046387677 @default.
- W2080805039 cites W2049048696 @default.
- W2080805039 cites W2055556486 @default.
- W2080805039 cites W2056060245 @default.
- W2080805039 cites W2058252463 @default.
- W2080805039 cites W2068318750 @default.
- W2080805039 cites W2089301383 @default.
- W2080805039 cites W2093936306 @default.
- W2080805039 cites W2114116986 @default.
- W2080805039 cites W2123884323 @default.
- W2080805039 cites W2124588032 @default.
- W2080805039 cites W2124705252 @default.
- W2080805039 cites W2138712613 @default.
- W2080805039 cites W2145651847 @default.
- W2080805039 cites W2149286574 @default.
- W2080805039 cites W2161108080 @default.
- W2080805039 cites W2165160195 @default.
- W2080805039 cites W2165310590 @default.
- W2080805039 cites W2168312153 @default.
- W2080805039 cites W2169083127 @default.
- W2080805039 cites W2324602863 @default.
- W2080805039 cites W4234262092 @default.
- W2080805039 cites W4240949546 @default.
- W2080805039 cites W4244302144 @default.
- W2080805039 cites W4247766607 @default.
- W2080805039 cites W71014585 @default.
- W2080805039 doi "https://doi.org/10.4236/arsci.2013.13007" @default.
- W2080805039 hasPublicationYear "2013" @default.
- W2080805039 type Work @default.
- W2080805039 sameAs 2080805039 @default.
- W2080805039 citedByCount "3" @default.
- W2080805039 countsByYear W20808050392017 @default.
- W2080805039 countsByYear W20808050392019 @default.
- W2080805039 countsByYear W20808050392023 @default.
- W2080805039 crossrefType "journal-article" @default.
- W2080805039 hasAuthorship W2080805039A5005680652 @default.
- W2080805039 hasAuthorship W2080805039A5011014484 @default.
- W2080805039 hasAuthorship W2080805039A5027040780 @default.
- W2080805039 hasAuthorship W2080805039A5028701315 @default.
- W2080805039 hasAuthorship W2080805039A5036108835 @default.
- W2080805039 hasAuthorship W2080805039A5056713141 @default.
- W2080805039 hasAuthorship W2080805039A5069212517 @default.
- W2080805039 hasAuthorship W2080805039A5073129043 @default.
- W2080805039 hasAuthorship W2080805039A5074006991 @default.
- W2080805039 hasAuthorship W2080805039A5086200879 @default.
- W2080805039 hasBestOaLocation W20808050391 @default.
- W2080805039 hasConcept C126322002 @default.
- W2080805039 hasConcept C134018914 @default.
- W2080805039 hasConcept C172680121 @default.
- W2080805039 hasConcept C185592680 @default.
- W2080805039 hasConcept C2776953305 @default.
- W2080805039 hasConcept C2777292125 @default.
- W2080805039 hasConcept C2778589496 @default.
- W2080805039 hasConcept C2779234561 @default.
- W2080805039 hasConcept C2779679481 @default.
- W2080805039 hasConcept C2780197806 @default.
- W2080805039 hasConcept C2781107390 @default.
- W2080805039 hasConcept C45167389 @default.
- W2080805039 hasConcept C54355233 @default.
- W2080805039 hasConcept C71924100 @default.
- W2080805039 hasConcept C86803240 @default.
- W2080805039 hasConcept C89560881 @default.
- W2080805039 hasConcept C95444343 @default.
- W2080805039 hasConceptScore W2080805039C126322002 @default.
- W2080805039 hasConceptScore W2080805039C134018914 @default.
- W2080805039 hasConceptScore W2080805039C172680121 @default.
- W2080805039 hasConceptScore W2080805039C185592680 @default.
- W2080805039 hasConceptScore W2080805039C2776953305 @default.
- W2080805039 hasConceptScore W2080805039C2777292125 @default.
- W2080805039 hasConceptScore W2080805039C2778589496 @default.