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- W2080809802 abstract "The efficacy of therapy with interferon (IFN)-β or -α for chronic hepatitis C is limited in long-term viral eradication and normalization of serum alanine transferase (ALT) levels. IFN-β, used intravenously, is shown to disappear from the circulation within 12 h after the injection, suggesting that the efficacy might be improved if IFN-β is injected at shorter intervals. Patients with chronic hepatitis C, diagnosed by liver histology and positive serum hepatitis C virus (HCV)-RNA, were randomly assigned to two groups and given IFN-β for 6 weeks. Patients received 6 MU every 24 h in group A and 3 MU every 12 h in group B. Fifty-four patients were enrolled in the trial, 28 in group A and 26 in group B. Demographic and clinical features of the patients before therapy did not differ between both groups. Proteinuria, thrombocytopenia and marked elevation of serum ALT levels developed more frequently in group B than in group A. Of seven patients in whom the therapy was ceased within 1 month in group B due to such adverse effects, three showed negative serum HCV-RNA during the follow-up period up to 12 months. Serum HCV-RNA disappeared in 95% of the patients in group B and 74% in group A at the end of the therapy. Multivariate logistic regression analysis revealed that the interval of IFN-β injections as well as serum HCV-RNA level were the important variables for determining the disappearance of serum HCV-RNA at the end of the therapy. IFN-β injected at 12-h intervals may be superior to the injections at 24-h intervals as a therapy with daily dose of 6 MU in the treatment of patients with chronic hepatitis C despite frequent adverse effects." @default.
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- W2080809802 date "1998-10-01" @default.
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- W2080809802 title "Randomized control trial of interferon-β injections at 12-h intervals as a therapy for chronic hepatitis C" @default.
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- W2080809802 doi "https://doi.org/10.1016/s1386-6346(98)00072-2" @default.
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