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- W2080810080 abstract "Certain inhibitors of normal deoxyribonucleic acid (DNA) synthesis have been found to be clinically effective antiviral agents. After the observation that idoxuridine (5-iodo-2′-deoxyuridine, IUdR, IDU) inhibited herpes simplex virus plaques in a cell culture system (Herrmann, 1961),<sup>1</sup>it was reported that this agent was highly active in curing herpes simplex keratitis in rabbits (Kaufman, 1962)<sup>2</sup>and in man (Kaufman et al, 1962).<sup>3</sup>Subsequently, another pyrimidine nucleoside, 1-β-d-arabinofuranosylcytosine hydrochloride (cytosine arabinoside or CA) was shown to cure herpes keratitis in rabbits (Underwood, 1962)<sup>4</sup>and in man (Kaufman and Maloney, 1963).<sup>5</sup>Because of the potential importance of these agents in antiviral chemotherapy, we continued our work on CA and expanded our studies to include other pyrimidine arabinosides. <h3>Materials and Methods</h3><h3>In Vivo.</h3> —Previously described procedures (Underwood, 1962)<sup>4</sup>used to produce experimental herpes simplex keratitis in rabbits were modified as follows. Two drops of 2%" @default.
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- W2080810080 date "1964-10-01" @default.
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- W2080810080 title "Cytosine Arabinoside (CA) and Other Nucleosides in Herpes Virus Infections" @default.
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- W2080810080 doi "https://doi.org/10.1001/archopht.1964.00970020505014" @default.
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