FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080810160> ?p ?o ?g. }

• W2080810160 endingPage "179" @default.
• W2080810160 startingPage "173" @default.
• W2080810160 abstract "The frequency of coronary heart disease (CHD) is increasing among HIV seropositive persons. This phenomenon may be related to HIV disease itself, the use of antiretroviral medications and increased length of survival, or the synergism of these factors. In this study we have calculated the 10-year CHD risk estimate and the prevalence of metabolic syndrome in a cohort of 118 HIV seropositive chronic drug users, including those who are on HAART with or without protease inhibitors (PI). The results showed that the 10-year coronary heart disease risk among the HIV seropositive drug users was 4.8 ± 5.7, which is within the range of results published for other HIV infected cohorts. The 10-year CHD risk was significantly higher in men (5.9±6.1, p<0.001) than in women (1.7±2.4), due to their gender and the pre-menopausal mean age of the women (39.4±7.3 years of age), despite a significantly higher rate of abdominal obesity (54.8% in women vs. 8.1% in men, p<0.001) and lower HDL (61.3% in women vs. 40% in men, p=0.042). The rate of metabolic syndrome among our female HIV seropositive drug users was significantly higher (29% vs 10.3%, p=0.013) compared to men (10.3%). Participants with metabolic syndrome had a significantly higher 10-year CHD risk (27.8% vs. 10.2%, p=0.041) and higher mean BMI (28.6 ± 4.1 vs. 24.2±4, p<0.001) than those without the syndrome. The predominant proportion of the cohort had a high viral load, suggesting that their use of illicit drugs has an influence on either adherence or effectiveness of antiretroviral medication. Increased viral load was significantly associated with metabolic syndrome (OR=2.23, 95% CI:1.12, 4.47; p=0.023), high fasting glucose (OR=1.61, 95% CI: 1.02, 2.55; p=0.042) and low HDL levels (OR=1.41, 95% CI: 1.01, 1.98; p=0.046), after controlling for age gender, smoking, PI exposure, BMI and CD4. HAART with or without PI did not significantly impact the 10-year CHD risk estimate or metabolic syndrome in this cohort. The estimated effect of PI, however, was positively and significantly related to triglyceride levels (effect estimate=95.81; 95% CI:39.40, 152.21; p<0.01) after controlling for age, gender, smoking, viral load, CD4 cell count and BMI. Heavy use of cigarettes and crack/cocaine was inversely associated with obesity (OR=0.84, 95% CI:0.67, 0.99; p=0.049; OR=0.43, 95% CI:0.19, 0.98; p=0.044, respectively), while use of marijuana tended to be associated with increased central obesity (p=0.08). Heavy cigarette smoking was significantly associated with low HDL (OR=3.06, 95% CI:1.18; 7.95, p=0.02). The significant association of higher viral load with CHD risk indicates that controlling viral load may be important in reducing CHD risk in HIV infected drug users." @default.
• W2080810160 created "2016-06-24" @default.
• W2080810160 creator A5010955652 @default.
• W2080810160 creator A5020279351 @default.
• W2080810160 creator A5053628483 @default.
• W2080810160 creator A5061697132 @default.
• W2080810160 creator A5069585223 @default.
• W2080810160 creator A5073339735 @default.
• W2080810160 creator A5075334425 @default.
• W2080810160 creator A5079246763 @default.
• W2080810160 creator A5090142867 @default.
• W2080810160 date "2006-03-01" @default.
• W2080810160 modified "2023-09-27" @default.
• W2080810160 title "Coronary Heart Disease (CHD) Risk Factors and Metabolic Syndrome in HIV-Positive Drug Users in Miami" @default.
• W2080810160 cites W124485063 @default.
• W2080810160 cites W1835442604 @default.
• W2080810160 cites W1978059911 @default.
• W2080810160 cites W1982772436 @default.
• W2080810160 cites W1986349550 @default.
• W2080810160 cites W1986697907 @default.
• W2080810160 cites W1992638484 @default.
• W2080810160 cites W2000219564 @default.
• W2080810160 cites W2003358339 @default.
• W2080810160 cites W2007061978 @default.
• W2080810160 cites W2007174639 @default.
• W2080810160 cites W2007742356 @default.
• W2080810160 cites W2008810901 @default.
• W2080810160 cites W2013255079 @default.
• W2080810160 cites W2039067102 @default.
• W2080810160 cites W2045595026 @default.
• W2080810160 cites W2045660745 @default.
• W2080810160 cites W2049863380 @default.
• W2080810160 cites W2058610272 @default.
• W2080810160 cites W2060825301 @default.
• W2080810160 cites W2061926910 @default.
• W2080810160 cites W2069396466 @default.
• W2080810160 cites W2078332901 @default.
• W2080810160 cites W2078807483 @default.
• W2080810160 cites W2088412858 @default.
• W2080810160 cites W2088643134 @default.
• W2080810160 cites W2101377509 @default.
• W2080810160 cites W2113243407 @default.
• W2080810160 cites W2118310760 @default.
• W2080810160 cites W2125891519 @default.
• W2080810160 cites W2147056877 @default.
• W2080810160 cites W2165884492 @default.
• W2080810160 cites W2332170987 @default.
• W2080810160 cites W2338565293 @default.
• W2080810160 cites W2340979442 @default.
• W2080810160 cites W2398388078 @default.
• W2080810160 cites W2413877209 @default.
• W2080810160 cites W2615584519 @default.
• W2080810160 doi "https://doi.org/10.3844/ajidsp.2006.173.179" @default.
• W2080810160 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2435190" @default.
• W2080810160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18568100" @default.
• W2080810160 hasPublicationYear "2006" @default.
• W2080810160 type Work @default.
• W2080810160 sameAs 2080810160 @default.
• W2080810160 citedByCount "32" @default.
• W2080810160 countsByYear W20808101602012 @default.
• W2080810160 countsByYear W20808101602013 @default.
• W2080810160 countsByYear W20808101602014 @default.
• W2080810160 countsByYear W20808101602015 @default.
• W2080810160 countsByYear W20808101602016 @default.
• W2080810160 countsByYear W20808101602017 @default.
• W2080810160 countsByYear W20808101602019 @default.
• W2080810160 countsByYear W20808101602020 @default.
• W2080810160 countsByYear W20808101602021 @default.
• W2080810160 crossrefType "journal-article" @default.
• W2080810160 hasAuthorship W2080810160A5010955652 @default.
• W2080810160 hasAuthorship W2080810160A5020279351 @default.
• W2080810160 hasAuthorship W2080810160A5053628483 @default.
• W2080810160 hasAuthorship W2080810160A5061697132 @default.
• W2080810160 hasAuthorship W2080810160A5069585223 @default.
• W2080810160 hasAuthorship W2080810160A5073339735 @default.
• W2080810160 hasAuthorship W2080810160A5075334425 @default.
• W2080810160 hasAuthorship W2080810160A5079246763 @default.
• W2080810160 hasAuthorship W2080810160A5090142867 @default.
• W2080810160 hasBestOaLocation W20808101602 @default.
• W2080810160 hasConcept C126322002 @default.
• W2080810160 hasConcept C203014093 @default.
• W2080810160 hasConcept C2777693730 @default.
• W2080810160 hasConcept C2780578515 @default.
• W2080810160 hasConcept C3013748606 @default.
• W2080810160 hasConcept C511355011 @default.
• W2080810160 hasConcept C71924100 @default.
• W2080810160 hasConcept C72563966 @default.
• W2080810160 hasConceptScore W2080810160C126322002 @default.
• W2080810160 hasConceptScore W2080810160C203014093 @default.
• W2080810160 hasConceptScore W2080810160C2777693730 @default.
• W2080810160 hasConceptScore W2080810160C2780578515 @default.
• W2080810160 hasConceptScore W2080810160C3013748606 @default.
• W2080810160 hasConceptScore W2080810160C511355011 @default.
• W2080810160 hasConceptScore W2080810160C71924100 @default.
• W2080810160 hasConceptScore W2080810160C72563966 @default.
• W2080810160 hasIssue "3" @default.
• W2080810160 hasLocation W20808101601 @default.
• W2080810160 hasLocation W20808101602 @default.

• next