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- W2080810172 abstract "Peptide catalyzed asymmetric epoxidation In the Juliá–Colonna epoxidation—discovered in the early 1980s—a homo-polymeric peptide such as poly-Leu catalyzes the highly enantioselective oxygen transfer from hydrogen peroxide to enones, mostly chalcones. Mechanistic proposals for this intriguing organocatalytic epoxidation involve a helical conformation of the peptide catalyst, and the N-terminus as the active site. It was shown later that even short peptides can be similarly effective—as little as five amino acid residues are sufficient to induce high enantioselectivity. However, a conformational analysis of such peptide catalysts in solution by using NMR spectroscopy has been missing. On p. 337 ff. of this issue, Berkessel, Schlörer, Díaz et al. provide evidence that the L-Leu hexamer, in DMSO solution, indeed forms the depicted one-turn 310-helix to a significant extent. Computational docking experiments of this helical structure with the proposed α-hydroperoxyenolate intermediate of the Juliá–Colonna epoxidation are in accord with the experimentally observed sense of induction. And yes indeed, the balcony shown is Julia's balcony in Verona." @default.
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- W2080810172 date "2012-02-29" @default.
- W2080810172 modified "2023-09-23" @default.
- W2080810172 title "Cover Picture: The L ‐Leu Hexamer, a Short and Highly Enantioselective Peptide Catalyst for the Juliá–Colonna Epoxidation: Stabilization of a Helical Conformation in DMSO (ChemCatChem 3/2012)" @default.
- W2080810172 doi "https://doi.org/10.1002/cctc.201290004" @default.
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