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- W2080811224 abstract "The purpose of this study was to assess the feasibility to determine fetal blood oxygen saturation with T2-weighted MR sequences using a fetal sheep model. To perform T2 measurements (1) in-vitro of fetal blood samples, (2) in-vivo in the fetal right and left ventricles. T2-measurements were performed on a 1.5 T scanner using a T2 preparation pulse in combination with a 3D balanced steady state free precession sequence repeated at different echo times (TE 30, 60, 90, 120, 150 msec). For in-vitro measurements blood samples from the fetal carotid artery with different oxygenation levels were measured. For in-vivo measurements eight sheep fetuses were examined during a control, hypoxic and recovery phase to perform T2-weighted scans of the fetal blood in the heart. Signal intensities in the left (LV) and right ventricle (RV) were measured to calculate the MR blood oxygen saturation (MR-sO2). During each phase fetal carotid artery sO2 was directly measured and correlated with MR-sO2. A Bland-Altman plot was performed. Fetal carotid artery-sO2 was 69% sO2% during control, 16% sO2% during hypoxemia and 67% sO2% during recovery. Mean values of the MR-sO2 were 49% sO2% and 40% sO2% for control, 6% sO2% and 3% sO2% for hypoxemia, 51% sO2% and 43% sO2% for recovery in LV and RV, respectively. Mean values of fetal carotid artery-sO2 and MR-sO2 were highly correlated (LV: r=0.87, p=0.000002 and RV: r=0.89, p=0.000001). According to the Bland-Altman plot MR-sO2 was lower compared to fetal carotid artery-sO2 (15% in LV and 20% in RV). Based on our preliminary results it seems to be possible to assess fetal oxygen saturation with MR oximetry. However, for practical application measurements have to be more accurate." @default.
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- W2080811224 date "2009-09-01" @default.
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- W2080811224 title "OP03.07: In-vivo MRI measurement of fetal blood oxygen saturation in cardiac ventricles of fetal sheep: a feasibility study" @default.
- W2080811224 doi "https://doi.org/10.1002/uog.6673" @default.
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