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- W2080826065 abstract "Ceruletide (CLT: 160 μg/kg, SC) produced a relatively long-lasting inhibition of haloperidol (HPD: 2 mg/kg, PO) catalepsy in rats. Neither bilateral vagotomies nor hypophysectomy abolished the anticataleptic effect of CLT. However, (−)-L-364,718 and proglumide blocked the effect of CLT. CLT (160 μg/kg) significantly inhibited HPD (2 mg/kg)-induced increase in dopamine (DA) release from the rat striatum. This effect of CLT was also antagonized by proglumide. These results suggest that CLT (160 μg/kg) primarily acts on cholecystokinin-A receptor in the brain, exerts some modulatory influence on HPD binding to striatal DA receptors via unknown neural pathways and, consequently, inhibits HPD catalepsy." @default.
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- W2080826065 date "1989-07-01" @default.
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- W2080826065 title "Inhibitory effect of ceruletide on haloperidol-induced catalepsy in rats" @default.
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- W2080826065 doi "https://doi.org/10.1016/0196-9781(89)90113-7" @default.
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