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- W2080827260 abstract "N-Desmethyldiazepam in plasma has been determined by gas chromatography with electron capture detection, using N-demethyltetrazepam as internal standard and a column filled with Poly-A 103 on Gas-Chrom Q. No prior transformation of benzodiazepines is necessary. The sensitivity is ca. 1 ng/ml and the recovery is ⩾ 70%. The method is particularly suitable for the pharmacokinetic study of dipotassium clorazepate: the amount of unchanged clorazepate may be estimated from the difference between the amount of N-desmethyldiazepam present initially and the total amount of N-desmethyldiazepam obtained after acidic treatment of the sample; the method is also useful for therapeutic control and for analytical toxicology." @default.
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- W2080827260 date "1978-01-01" @default.
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- W2080827260 title "Determination of N-desmethyldiazepam in plasma by gas chromatography with an internal standard" @default.
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- W2080827260 doi "https://doi.org/10.1016/s0021-9673(00)85146-8" @default.
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