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- W2080830076 endingPage "1039" @default.
- W2080830076 startingPage "1024" @default.
- W2080830076 abstract "In brain stem slices from neonatal ( postnatal days 0–4) CD-1 mice, muscarinic ACh receptors (MAChRs) increased rhythmic inspiratory-related and tonic hypoglossal nerve discharge and depolarized single hypoglossal motoneurons (HMs) via an inward current without changing input resistance. These responses were blocked by the MAChR antagonist 1,1-dimethyl-4-diphenylacetoxypiperidinium iodide (4-DAMP; 100 nM). MAChRs shifted voltage-dependent activation of the hyperpolarization-activated cation current to more positive levels. MAChRs increased the HM repetitive firing rate and decreased rheobase, with both effects being blocked by 4-DAMP. Muscarinic agonists reduced the afterhyperpolarization of single action potentials (APs), suggesting that small-conductance Ca 2+ -dependent K + current inhibition increased the HM firing rate. Muscarinic agonists also reduced the AP amplitude and slowed its time course, suggesting that MAChRs inhibited voltage-gated Na + channels. To compare muscarinic excitation of single HMs to muscarinic excitatory effects on motor output in thicker brain stem slices requiring higher extracellular K + for rhythmic activity, we tested the effects of muscarinic agonists on single HM excitability in high-K + artificial cerebrospinal fluid (aCSF). In high-K + aCSF, muscarinic agonists still depolarized HMs and altered AP size and shape, as in standard aCSF, but did not increase the steady-state firing rate, decrease afterhyperpolarization, or alter threshold potential. These results indicate that the basic cellular response of HMs to muscarinic receptors is excitatory, via a number of distinct mechanisms, and that this excitatory response will be largely preserved in rhythmically active brain stem slices." @default.
- W2080830076 created "2016-06-24" @default.
- W2080830076 creator A5034558153 @default.
- W2080830076 creator A5036596031 @default.
- W2080830076 creator A5041408110 @default.
- W2080830076 date "2012-10-01" @default.
- W2080830076 modified "2023-09-23" @default.
- W2080830076 title "Muscarinic acetylcholine receptors enhance neonatal mouse hypoglossal motoneuron excitability in vitro" @default.
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