FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080831030> ?p ?o ?g. }

• W2080831030 endingPage "e88808" @default.
• W2080831030 startingPage "e88808" @default.
• W2080831030 abstract "Dose addition, a commonly used concept in toxicology for the prediction of chemical mixture effects, cannot readily be applied to mixtures of partial agonists with differing maximal effects. Due to its mathematical features, effect levels that exceed the maximal effect of the least efficacious compound present in the mixture, cannot be calculated. This poses problems when dealing with mixtures likely to be encountered in realistic assessment situations where chemicals often show differing maximal effects. To overcome this limitation, we developed a pragmatic solution that extrapolates the toxic units of partial agonists to effect levels beyond their maximal efficacy. We extrapolated different additivity expectations that reflect theoretically possible extremes and validated this approach with a mixture of 21 estrogenic chemicals in the E-Screen. This assay measures the proliferation of human epithelial breast cancers. We found that the dose-response curves of the estrogenic agents exhibited widely varying shapes, slopes and maximal effects, which made it necessary to extrapolate mixture responses above 14% proliferation. Our toxic unit extrapolation approach predicted all mixture responses accurately. It extends the applicability of dose addition to combinations of agents with differing saturating effects and removes an important bottleneck that has severely hampered the use of dose addition in the past." @default.
• W2080831030 created "2016-06-24" @default.
• W2080831030 creator A5045993118 @default.
• W2080831030 creator A5061212305 @default.
• W2080831030 creator A5063374927 @default.
• W2080831030 date "2014-02-12" @default.
• W2080831030 modified "2023-09-24" @default.
• W2080831030 title "Extending the Applicability of the Dose Addition Model to the Assessment of Chemical Mixtures of Partial Agonists by Using a Novel Toxic Unit Extrapolation Method" @default.
• W2080831030 cites W15349034 @default.
• W2080831030 cites W1975949085 @default.
• W2080831030 cites W1978785960 @default.
• W2080831030 cites W1985693836 @default.
• W2080831030 cites W1985956131 @default.
• W2080831030 cites W1997614456 @default.
• W2080831030 cites W2005013037 @default.
• W2080831030 cites W2020579057 @default.
• W2080831030 cites W2033587232 @default.
• W2080831030 cites W2069368513 @default.
• W2080831030 cites W2118057169 @default.
• W2080831030 cites W2128706703 @default.
• W2080831030 cites W2135605464 @default.
• W2080831030 cites W2165897849 @default.
• W2080831030 cites W2167070287 @default.
• W2080831030 cites W2169596673 @default.
• W2080831030 cites W3106889297 @default.
• W2080831030 doi "https://doi.org/10.1371/journal.pone.0088808" @default.
• W2080831030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3923049" @default.
• W2080831030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24533151" @default.
• W2080831030 hasPublicationYear "2014" @default.
• W2080831030 type Work @default.
• W2080831030 sameAs 2080831030 @default.
• W2080831030 citedByCount "44" @default.
• W2080831030 countsByYear W20808310302014 @default.
• W2080831030 countsByYear W20808310302015 @default.
• W2080831030 countsByYear W20808310302016 @default.
• W2080831030 countsByYear W20808310302017 @default.
• W2080831030 countsByYear W20808310302018 @default.
• W2080831030 countsByYear W20808310302019 @default.
• W2080831030 countsByYear W20808310302020 @default.
• W2080831030 countsByYear W20808310302021 @default.
• W2080831030 countsByYear W20808310302022 @default.
• W2080831030 countsByYear W20808310302023 @default.
• W2080831030 crossrefType "journal-article" @default.
• W2080831030 hasAuthorship W2080831030A5045993118 @default.
• W2080831030 hasAuthorship W2080831030A5061212305 @default.
• W2080831030 hasAuthorship W2080831030A5063374927 @default.
• W2080831030 hasBestOaLocation W20808310301 @default.
• W2080831030 hasConcept C105795698 @default.
• W2080831030 hasConcept C132459708 @default.
• W2080831030 hasConcept C134306372 @default.
• W2080831030 hasConcept C149635348 @default.
• W2080831030 hasConcept C170493617 @default.
• W2080831030 hasConcept C185592680 @default.
• W2080831030 hasConcept C186060115 @default.
• W2080831030 hasConcept C2778938600 @default.
• W2080831030 hasConcept C2780513914 @default.
• W2080831030 hasConcept C28826006 @default.
• W2080831030 hasConcept C33923547 @default.
• W2080831030 hasConcept C38803922 @default.
• W2080831030 hasConcept C41008148 @default.
• W2080831030 hasConcept C55493867 @default.
• W2080831030 hasConcept C58732023 @default.
• W2080831030 hasConcept C86803240 @default.
• W2080831030 hasConcept C98274493 @default.
• W2080831030 hasConceptScore W2080831030C105795698 @default.
• W2080831030 hasConceptScore W2080831030C132459708 @default.
• W2080831030 hasConceptScore W2080831030C134306372 @default.
• W2080831030 hasConceptScore W2080831030C149635348 @default.
• W2080831030 hasConceptScore W2080831030C170493617 @default.
• W2080831030 hasConceptScore W2080831030C185592680 @default.
• W2080831030 hasConceptScore W2080831030C186060115 @default.
• W2080831030 hasConceptScore W2080831030C2778938600 @default.
• W2080831030 hasConceptScore W2080831030C2780513914 @default.
• W2080831030 hasConceptScore W2080831030C28826006 @default.
• W2080831030 hasConceptScore W2080831030C33923547 @default.
• W2080831030 hasConceptScore W2080831030C38803922 @default.
• W2080831030 hasConceptScore W2080831030C41008148 @default.
• W2080831030 hasConceptScore W2080831030C55493867 @default.
• W2080831030 hasConceptScore W2080831030C58732023 @default.
• W2080831030 hasConceptScore W2080831030C86803240 @default.
• W2080831030 hasConceptScore W2080831030C98274493 @default.
• W2080831030 hasIssue "2" @default.
• W2080831030 hasLocation W20808310301 @default.
• W2080831030 hasLocation W20808310302 @default.
• W2080831030 hasLocation W20808310303 @default.
• W2080831030 hasLocation W20808310304 @default.
• W2080831030 hasLocation W20808310305 @default.
• W2080831030 hasLocation W20808310306 @default.
• W2080831030 hasOpenAccess W2080831030 @default.
• W2080831030 hasPrimaryLocation W20808310301 @default.
• W2080831030 hasRelatedWork W2058581251 @default.
• W2080831030 hasRelatedWork W2105594625 @default.
• W2080831030 hasRelatedWork W2353647904 @default.
• W2080831030 hasRelatedWork W2354251581 @default.
• W2080831030 hasRelatedWork W2357461155 @default.
• W2080831030 hasRelatedWork W2384129116 @default.
• W2080831030 hasRelatedWork W2748952813 @default.
• W2080831030 hasRelatedWork W2899084033 @default.

• next