FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080831364> ?p ?o ?g. }

• W2080831364 endingPage "408" @default.
• W2080831364 startingPage "402" @default.
• W2080831364 abstract "Successful navigation requires interactions among multiple but overlapping neural pathways mediating distinct capabilities, including egocentric (self-oriented, route-based) and allocentric (spatial, map-based) learning. Route-based navigation has been shown to be impaired following acute exposure to the dopaminergic (DA) drugs (+)-methamphetamine and (+)-amphetamine, but not the serotoninergic (5-HT) drugs (±)-3,4-methylenedioxymethamphetamine or (±)-fenfluramine. The dopaminergic-rich neostriatum is involved in both allocentric and egocentric navigation. This experiment tested whether dorsal striatal DA loss using bilateral 6-hydroxydopamine (6-OHDA) injections impaired one or both types of navigation. Two weeks following 6-OHDA injections, rats began testing in the Cincinnati water maze (CWM) followed by the Morris water maze (MWM) for route-based and spatial navigation, respectively. 6-OHDA treatment significantly increased latency and errors in the CWM and path length, latency, and cumulative distance in the MWM with no difference on cued MWM trials. Neostriatal DA levels were reduced by 80% at 2 and 7 weeks post-treatment. In addition, 6-OHDA increased DA turnover and decreased norepinephrine (NE) levels. 6-OHDA injections did not alter monoamine levels in the prefrontal cortex. The data support that neostriatal DA modulates both types of navigation." @default.
• W2080831364 created "2016-06-24" @default.
• W2080831364 creator A5059572622 @default.
• W2080831364 creator A5066856401 @default.
• W2080831364 creator A5082804242 @default.
• W2080831364 creator A5089828912 @default.
• W2080831364 date "2012-05-01" @default.
• W2080831364 modified "2023-10-06" @default.
• W2080831364 title "Dorsal striatal dopamine depletion impairs both allocentric and egocentric navigation in rats" @default.
• W2080831364 cites W1970524798 @default.
• W2080831364 cites W1973529564 @default.
• W2080831364 cites W1973772115 @default.
• W2080831364 cites W1976652826 @default.
• W2080831364 cites W1979595031 @default.
• W2080831364 cites W1980237303 @default.
• W2080831364 cites W1983842854 @default.
• W2080831364 cites W1983866101 @default.
• W2080831364 cites W1984315717 @default.
• W2080831364 cites W1984708543 @default.
• W2080831364 cites W1994059999 @default.
• W2080831364 cites W1997994621 @default.
• W2080831364 cites W1999447306 @default.
• W2080831364 cites W2001760166 @default.
• W2080831364 cites W2002724115 @default.
• W2080831364 cites W2016261700 @default.
• W2080831364 cites W2017169966 @default.
• W2080831364 cites W2017255174 @default.
• W2080831364 cites W2029680410 @default.
• W2080831364 cites W2036987600 @default.
• W2080831364 cites W2041660508 @default.
• W2080831364 cites W2043896273 @default.
• W2080831364 cites W2050192143 @default.
• W2080831364 cites W2054029447 @default.
• W2080831364 cites W2056621949 @default.
• W2080831364 cites W2059164795 @default.
• W2080831364 cites W2059351781 @default.
• W2080831364 cites W2059389314 @default.
• W2080831364 cites W2067313980 @default.
• W2080831364 cites W2074901704 @default.
• W2080831364 cites W2082446434 @default.
• W2080831364 cites W2082928238 @default.
• W2080831364 cites W2089291555 @default.
• W2080831364 cites W2089586993 @default.
• W2080831364 cites W2096518324 @default.
• W2080831364 cites W2114681289 @default.
• W2080831364 cites W2115376779 @default.
• W2080831364 cites W2115563905 @default.
• W2080831364 cites W2116821483 @default.
• W2080831364 cites W2145107163 @default.
• W2080831364 cites W2148741637 @default.
• W2080831364 cites W2158341864 @default.
• W2080831364 cites W2164235884 @default.
• W2080831364 cites W4232217111 @default.
• W2080831364 cites W4233631110 @default.
• W2080831364 cites W4234595117 @default.
• W2080831364 doi "https://doi.org/10.1016/j.nlm.2012.03.004" @default.
• W2080831364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4131757" @default.
• W2080831364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22465436" @default.
• W2080831364 hasPublicationYear "2012" @default.
• W2080831364 type Work @default.
• W2080831364 sameAs 2080831364 @default.
• W2080831364 citedByCount "52" @default.
• W2080831364 countsByYear W20808313642013 @default.
• W2080831364 countsByYear W20808313642014 @default.
• W2080831364 countsByYear W20808313642015 @default.
• W2080831364 countsByYear W20808313642016 @default.
• W2080831364 countsByYear W20808313642017 @default.
• W2080831364 countsByYear W20808313642018 @default.
• W2080831364 countsByYear W20808313642019 @default.
• W2080831364 countsByYear W20808313642020 @default.
• W2080831364 countsByYear W20808313642021 @default.
• W2080831364 countsByYear W20808313642022 @default.
• W2080831364 crossrefType "journal-article" @default.
• W2080831364 hasAuthorship W2080831364A5059572622 @default.
• W2080831364 hasAuthorship W2080831364A5066856401 @default.
• W2080831364 hasAuthorship W2080831364A5082804242 @default.
• W2080831364 hasAuthorship W2080831364A5089828912 @default.
• W2080831364 hasBestOaLocation W20808313642 @default.
• W2080831364 hasConcept C12515866 @default.
• W2080831364 hasConcept C126322002 @default.
• W2080831364 hasConcept C137183658 @default.
• W2080831364 hasConcept C15744967 @default.
• W2080831364 hasConcept C169760540 @default.
• W2080831364 hasConcept C170493617 @default.
• W2080831364 hasConcept C185592680 @default.
• W2080831364 hasConcept C2775864247 @default.
• W2080831364 hasConcept C2780200011 @default.
• W2080831364 hasConcept C2781161787 @default.
• W2080831364 hasConcept C37000724 @default.
• W2080831364 hasConcept C44752575 @default.
• W2080831364 hasConcept C513476851 @default.
• W2080831364 hasConcept C71924100 @default.
• W2080831364 hasConceptScore W2080831364C12515866 @default.
• W2080831364 hasConceptScore W2080831364C126322002 @default.
• W2080831364 hasConceptScore W2080831364C137183658 @default.
• W2080831364 hasConceptScore W2080831364C15744967 @default.
• W2080831364 hasConceptScore W2080831364C169760540 @default.
• W2080831364 hasConceptScore W2080831364C170493617 @default.

• next