FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080832088> ?p ?o ?g. }

• W2080832088 endingPage "47" @default.
• W2080832088 startingPage "38" @default.
• W2080832088 abstract "The p53 tumor suppressor modulates cellular response to stress through both transcriptional and post-transcriptional mechanisms. Elucidation of the downstream targets of p53 following cell stress will aid in our understanding of the pathways involved in cellular adaptation to stressful stimuli. Here, we demonstrate that the TGF-β superfamily member, and putative tumor suppressor, prostate-derived factor (PDF)/NSAID-activated gene (NAG)-1/macrophage inhibitory cytokine (MIC)-1 is induced in LNCaP human prostate cancer cells following treatment with the DNA-damaging agent, doxorubicin, culture under hypoxic conditions and by the hypoxia mimetic, cobalt chloride. Additionally, PDF expression was induced by increasing cell density. Expression of dominant negative p53 in LNCaP cells blocked induction of PDF mRNA and protein demonstrating the requirement for functional p53 in PDF induction by these stimuli. DNA damage and hypoxia resulted in increased p53 protein accumulation indicating that PDF expression may be controlled by cellular levels of p53. We also show the requirement for de novo protein synthesis in PDF induction by hypoxia and DNA damage. Increased PDF mRNA stability in response to hypoxia and cobalt chloride, but not doxorubicin, indicates that p53-dependent induction of PDF expression occurs via diverse mechanisms. Thus, PDF may represent a novel target of p53 in response to cell stress." @default.
• W2080832088 created "2016-06-24" @default.
• W2080832088 creator A5003783985 @default.
• W2080832088 creator A5072384926 @default.
• W2080832088 creator A5073212586 @default.
• W2080832088 date "2009-05-01" @default.
• W2080832088 modified "2023-09-25" @default.
• W2080832088 title "p53 controls prostate-derived factor/macrophage inhibitory cytokine/NSAID-activated gene expression in response to cell density, DNA damage and hypoxia through diverse mechanisms" @default.
• W2080832088 cites W1578151093 @default.
• W2080832088 cites W1966773608 @default.
• W2080832088 cites W1972842856 @default.
• W2080832088 cites W1977621160 @default.
• W2080832088 cites W1978125763 @default.
• W2080832088 cites W1989468717 @default.
• W2080832088 cites W1991494214 @default.
• W2080832088 cites W1991691622 @default.
• W2080832088 cites W1993170641 @default.
• W2080832088 cites W1993784521 @default.
• W2080832088 cites W1997673869 @default.
• W2080832088 cites W2022851687 @default.
• W2080832088 cites W2025969523 @default.
• W2080832088 cites W2027484188 @default.
• W2080832088 cites W2028999918 @default.
• W2080832088 cites W2030908134 @default.
• W2080832088 cites W2038291224 @default.
• W2080832088 cites W2040670368 @default.
• W2080832088 cites W2049385227 @default.
• W2080832088 cites W2051653133 @default.
• W2080832088 cites W2053042661 @default.
• W2080832088 cites W2062580028 @default.
• W2080832088 cites W2063815648 @default.
• W2080832088 cites W2065858724 @default.
• W2080832088 cites W2069397587 @default.
• W2080832088 cites W2074735516 @default.
• W2080832088 cites W2075103181 @default.
• W2080832088 cites W2088844005 @default.
• W2080832088 cites W2094280155 @default.
• W2080832088 cites W2107277218 @default.
• W2080832088 cites W2109560931 @default.
• W2080832088 cites W2115206585 @default.
• W2080832088 cites W2123086846 @default.
• W2080832088 cites W2123607020 @default.
• W2080832088 cites W2126294962 @default.
• W2080832088 cites W2126527070 @default.
• W2080832088 cites W2138563742 @default.
• W2080832088 cites W2151382436 @default.
• W2080832088 cites W2160657822 @default.
• W2080832088 cites W2168430622 @default.
• W2080832088 cites W2169552095 @default.
• W2080832088 cites W2169658646 @default.
• W2080832088 cites W2170169143 @default.
• W2080832088 cites W2338655541 @default.
• W2080832088 doi "https://doi.org/10.1016/j.canlet.2008.11.013" @default.
• W2080832088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19100681" @default.
• W2080832088 hasPublicationYear "2009" @default.
• W2080832088 type Work @default.
• W2080832088 sameAs 2080832088 @default.
• W2080832088 citedByCount "37" @default.
• W2080832088 countsByYear W20808320882012 @default.
• W2080832088 countsByYear W20808320882013 @default.
• W2080832088 countsByYear W20808320882014 @default.
• W2080832088 countsByYear W20808320882015 @default.
• W2080832088 countsByYear W20808320882016 @default.
• W2080832088 countsByYear W20808320882017 @default.
• W2080832088 countsByYear W20808320882018 @default.
• W2080832088 countsByYear W20808320882019 @default.
• W2080832088 countsByYear W20808320882020 @default.
• W2080832088 countsByYear W20808320882021 @default.
• W2080832088 countsByYear W20808320882022 @default.
• W2080832088 countsByYear W20808320882023 @default.
• W2080832088 crossrefType "journal-article" @default.
• W2080832088 hasAuthorship W2080832088A5003783985 @default.
• W2080832088 hasAuthorship W2080832088A5072384926 @default.
• W2080832088 hasAuthorship W2080832088A5073212586 @default.
• W2080832088 hasConcept C104317684 @default.
• W2080832088 hasConcept C121608353 @default.
• W2080832088 hasConcept C143425029 @default.
• W2080832088 hasConcept C150194340 @default.
• W2080832088 hasConcept C153911025 @default.
• W2080832088 hasConcept C156902634 @default.
• W2080832088 hasConcept C203014093 @default.
• W2080832088 hasConcept C2778690821 @default.
• W2080832088 hasConcept C2779723316 @default.
• W2080832088 hasConcept C2780096491 @default.
• W2080832088 hasConcept C502942594 @default.
• W2080832088 hasConcept C54355233 @default.
• W2080832088 hasConcept C552990157 @default.
• W2080832088 hasConcept C55493867 @default.
• W2080832088 hasConcept C78604142 @default.
• W2080832088 hasConcept C86803240 @default.
• W2080832088 hasConcept C95444343 @default.
• W2080832088 hasConcept C96232424 @default.
• W2080832088 hasConceptScore W2080832088C104317684 @default.
• W2080832088 hasConceptScore W2080832088C121608353 @default.
• W2080832088 hasConceptScore W2080832088C143425029 @default.
• W2080832088 hasConceptScore W2080832088C150194340 @default.
• W2080832088 hasConceptScore W2080832088C153911025 @default.
• W2080832088 hasConceptScore W2080832088C156902634 @default.

• next