Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080832391> ?p ?o ?g. }
- W2080832391 endingPage "2143" @default.
- W2080832391 startingPage "2131" @default.
- W2080832391 abstract "The DNA replication checkpoint (DRC) monitors and responds to stalled replication forks to prevent genomic instability. How core replication factors integrate into this phosphorylation cascade is incompletely understood. Here, through analysis of a unique mcm allele targeting a specific ATPase active site (mcm2DENQ), we show that the Mcm2-7 replicative helicase has a novel DRC function as part of the signal transduction cascade. This allele exhibits normal downstream mediator (Mrc1) phosphorylation, implying DRC sensor kinase activation. However, the mutant also exhibits defective effector kinase (Rad53) activation and classic DRC phenotypes. Our previous in vitro analysis showed that the mcm2DENQ mutation prevents a specific conformational change in the Mcm2-7 hexamer. We infer that this conformational change is required for its DRC role and propose that it allosterically facilitates Rad53 activation to ensure a replication-specific checkpoint response." @default.
- W2080832391 created "2016-06-24" @default.
- W2080832391 creator A5007034020 @default.
- W2080832391 creator A5024558337 @default.
- W2080832391 creator A5048445038 @default.
- W2080832391 creator A5055972570 @default.
- W2080832391 creator A5070421009 @default.
- W2080832391 creator A5076771592 @default.
- W2080832391 date "2015-06-01" @default.
- W2080832391 modified "2023-10-12" @default.
- W2080832391 title "Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate" @default.
- W2080832391 cites W1496762058 @default.
- W2080832391 cites W1538419182 @default.
- W2080832391 cites W1564916342 @default.
- W2080832391 cites W1566625041 @default.
- W2080832391 cites W1752089945 @default.
- W2080832391 cites W1866059572 @default.
- W2080832391 cites W1964284285 @default.
- W2080832391 cites W1964439976 @default.
- W2080832391 cites W1966036904 @default.
- W2080832391 cites W1969321207 @default.
- W2080832391 cites W1970732313 @default.
- W2080832391 cites W1971799079 @default.
- W2080832391 cites W1975001355 @default.
- W2080832391 cites W1979544330 @default.
- W2080832391 cites W1986121915 @default.
- W2080832391 cites W1991539934 @default.
- W2080832391 cites W1991917259 @default.
- W2080832391 cites W1993478070 @default.
- W2080832391 cites W1993579360 @default.
- W2080832391 cites W1994183178 @default.
- W2080832391 cites W1994514609 @default.
- W2080832391 cites W1994605002 @default.
- W2080832391 cites W1998061899 @default.
- W2080832391 cites W1999341930 @default.
- W2080832391 cites W2001284527 @default.
- W2080832391 cites W2006765383 @default.
- W2080832391 cites W2006961239 @default.
- W2080832391 cites W2018289272 @default.
- W2080832391 cites W2022562381 @default.
- W2080832391 cites W2027594270 @default.
- W2080832391 cites W2029369774 @default.
- W2080832391 cites W2034206561 @default.
- W2080832391 cites W2037728125 @default.
- W2080832391 cites W2040860750 @default.
- W2080832391 cites W2043895957 @default.
- W2080832391 cites W2049171516 @default.
- W2080832391 cites W2049372439 @default.
- W2080832391 cites W2050241400 @default.
- W2080832391 cites W2050659339 @default.
- W2080832391 cites W2055604308 @default.
- W2080832391 cites W2056590571 @default.
- W2080832391 cites W2058093809 @default.
- W2080832391 cites W2062056341 @default.
- W2080832391 cites W2066975479 @default.
- W2080832391 cites W2078740028 @default.
- W2080832391 cites W2079803074 @default.
- W2080832391 cites W2083942911 @default.
- W2080832391 cites W2085176501 @default.
- W2080832391 cites W2092883977 @default.
- W2080832391 cites W2093703127 @default.
- W2080832391 cites W2098324291 @default.
- W2080832391 cites W2102433010 @default.
- W2080832391 cites W2106130068 @default.
- W2080832391 cites W2108221620 @default.
- W2080832391 cites W2108231450 @default.
- W2080832391 cites W2110691960 @default.
- W2080832391 cites W2115009474 @default.
- W2080832391 cites W2116075382 @default.
- W2080832391 cites W2119902784 @default.
- W2080832391 cites W2123847083 @default.
- W2080832391 cites W2133643647 @default.
- W2080832391 cites W2136911930 @default.
- W2080832391 cites W2137530487 @default.
- W2080832391 cites W2142416165 @default.
- W2080832391 cites W2145317354 @default.
- W2080832391 cites W2148530409 @default.
- W2080832391 cites W2149888835 @default.
- W2080832391 cites W2151122676 @default.
- W2080832391 cites W2152125010 @default.
- W2080832391 cites W2152414953 @default.
- W2080832391 cites W2159168998 @default.
- W2080832391 cites W2161807953 @default.
- W2080832391 cites W2167165923 @default.
- W2080832391 cites W2169221124 @default.
- W2080832391 cites W2170829529 @default.
- W2080832391 cites W2413386319 @default.
- W2080832391 doi "https://doi.org/10.1128/mcb.01357-14" @default.
- W2080832391 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4438241" @default.
- W2080832391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25870112" @default.
- W2080832391 hasPublicationYear "2015" @default.
- W2080832391 type Work @default.
- W2080832391 sameAs 2080832391 @default.
- W2080832391 citedByCount "13" @default.
- W2080832391 countsByYear W20808323912016 @default.
- W2080832391 countsByYear W20808323912017 @default.
- W2080832391 countsByYear W20808323912018 @default.
- W2080832391 countsByYear W20808323912019 @default.