FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080840982> ?p ?o ?g. }

• W2080840982 endingPage "562" @default.
• W2080840982 startingPage "555" @default.
• W2080840982 abstract "Summary Accumulating evidence suggests that intestinal epithelial cells (IECs) constitutively express the immunoregulatory cytokine interleukin (IL)-18. IECs also serve as the host cell for the intracellular parasitic protozoan Cryptosporidium parvum. In the present study, C. parvum infection of a human enterocyte cell-line HCT-8 resulted in increased expression of IL-18 mRNA as measured by quantitative reverse transcription–polymerase chain reaction (RT-PCR). IL-18 protein was detected in control uninfected cells and following infection there was increased expression as measured by enzyme-linked immunosorbent assay (ELISA). Gene expression revealed the presence of the IL-18 receptor subunits not only in cell-lines but also in freshly isolated IECs, suggesting that IL-18-mediated signalling events may contribute to epithelial host defence during infection. Recombinant IL-18 inhibited intracellular development of the parasite in HCT-8 and HT-29 cells. Increased expression of bactericidal antibiotic peptides LL-37 and α-defensin 2 by IL-18 in HCT-8 and HT-29 cells may represent one mode of action by which this pluripotent cytokine aids in limiting the development of intracellular pathogens such as C. parvum in the gastrointestinal tract." @default.
• W2080840982 created "2016-06-24" @default.
• W2080840982 creator A5014086728 @default.
• W2080840982 creator A5019987721 @default.
• W2080840982 creator A5022599462 @default.
• W2080840982 creator A5026403591 @default.
• W2080840982 creator A5051452881 @default.
• W2080840982 creator A5068777288 @default.
• W2080840982 date "2006-07-12" @default.
• W2080840982 modified "2023-10-02" @default.
• W2080840982 title "A potential role for interleukin-18 in inhibition of the development of<i>Cryptosporidium parvum</i>" @default.
• W2080840982 cites W1501206772 @default.
• W2080840982 cites W1544824212 @default.
• W2080840982 cites W1579888339 @default.
• W2080840982 cites W1586925433 @default.
• W2080840982 cites W1926711481 @default.
• W2080840982 cites W1935484278 @default.
• W2080840982 cites W195731949 @default.
• W2080840982 cites W1967251205 @default.
• W2080840982 cites W1973139259 @default.
• W2080840982 cites W1996729081 @default.
• W2080840982 cites W2008382495 @default.
• W2080840982 cites W2011843272 @default.
• W2080840982 cites W2019383068 @default.
• W2080840982 cites W2034427745 @default.
• W2080840982 cites W2042352158 @default.
• W2080840982 cites W2043074209 @default.
• W2080840982 cites W2044162906 @default.
• W2080840982 cites W2052895824 @default.
• W2080840982 cites W2060282267 @default.
• W2080840982 cites W2065057278 @default.
• W2080840982 cites W2070597700 @default.
• W2080840982 cites W2073549824 @default.
• W2080840982 cites W2099540175 @default.
• W2080840982 cites W2099872746 @default.
• W2080840982 cites W2100864093 @default.
• W2080840982 cites W2101581724 @default.
• W2080840982 cites W2102895007 @default.
• W2080840982 cites W2112066013 @default.
• W2080840982 cites W2112560263 @default.
• W2080840982 cites W2117252842 @default.
• W2080840982 cites W2119999909 @default.
• W2080840982 cites W2120872281 @default.
• W2080840982 cites W2120886013 @default.
• W2080840982 cites W2130866697 @default.
• W2080840982 cites W2131543814 @default.
• W2080840982 cites W2143971425 @default.
• W2080840982 cites W2146965501 @default.
• W2080840982 cites W2166666225 @default.
• W2080840982 cites W2170091723 @default.
• W2080840982 cites W4313306023 @default.
• W2080840982 cites W4313379471 @default.
• W2080840982 cites W60879456 @default.
• W2080840982 doi "https://doi.org/10.1111/j.1365-2249.2006.03159.x" @default.
• W2080840982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1809716" @default.
• W2080840982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16907926" @default.
• W2080840982 hasPublicationYear "2006" @default.
• W2080840982 type Work @default.
• W2080840982 sameAs 2080840982 @default.
• W2080840982 citedByCount "42" @default.
• W2080840982 countsByYear W20808409822012 @default.
• W2080840982 countsByYear W20808409822013 @default.
• W2080840982 countsByYear W20808409822014 @default.
• W2080840982 countsByYear W20808409822015 @default.
• W2080840982 countsByYear W20808409822016 @default.
• W2080840982 countsByYear W20808409822017 @default.
• W2080840982 countsByYear W20808409822018 @default.
• W2080840982 countsByYear W20808409822020 @default.
• W2080840982 countsByYear W20808409822021 @default.
• W2080840982 countsByYear W20808409822022 @default.
• W2080840982 countsByYear W20808409822023 @default.
• W2080840982 crossrefType "journal-article" @default.
• W2080840982 hasAuthorship W2080840982A5014086728 @default.
• W2080840982 hasAuthorship W2080840982A5019987721 @default.
• W2080840982 hasAuthorship W2080840982A5022599462 @default.
• W2080840982 hasAuthorship W2080840982A5026403591 @default.
• W2080840982 hasAuthorship W2080840982A5051452881 @default.
• W2080840982 hasAuthorship W2080840982A5068777288 @default.
• W2080840982 hasBestOaLocation W20808409822 @default.
• W2080840982 hasConcept C153726182 @default.
• W2080840982 hasConcept C153911025 @default.
• W2080840982 hasConcept C203014093 @default.
• W2080840982 hasConcept C2777795018 @default.
• W2080840982 hasConcept C2777882243 @default.
• W2080840982 hasConcept C2778690821 @default.
• W2080840982 hasConcept C2779604457 @default.
• W2080840982 hasConcept C54355233 @default.
• W2080840982 hasConcept C55493867 @default.
• W2080840982 hasConcept C79879829 @default.
• W2080840982 hasConcept C81885089 @default.
• W2080840982 hasConcept C86803240 @default.
• W2080840982 hasConcept C89423630 @default.
• W2080840982 hasConcept C95444343 @default.
• W2080840982 hasConceptScore W2080840982C153726182 @default.
• W2080840982 hasConceptScore W2080840982C153911025 @default.
• W2080840982 hasConceptScore W2080840982C203014093 @default.
• W2080840982 hasConceptScore W2080840982C2777795018 @default.
• W2080840982 hasConceptScore W2080840982C2777882243 @default.

• next