Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080843360> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2080843360 endingPage "470" @default.
- W2080843360 startingPage "465" @default.
- W2080843360 abstract "1 Labetalol pharmacokinetics and concentration-effect relationships following intravenous administration have been studied in 10 women during the last trimester of pregnancies complicated by hypertension, in seven of these women postpartum (when normotensive) and in 10 normotensive female volunteers. 2 The clearance and volume of distribution of labetalol were the same in all three groups. Clearance values (1 min-1) were: pregnant, 2.16 (range 1.54-3.14); postpartum 2.35 (1.56-3.85); controls 1.96 (0.98-2.61). Volumes of distribution (1) were: pregnant 274 (250-547); postpartum 407 (248-701); controls 234 (186-415). 3 A linear model relating labetalol concentration to effect successfully described the antihypertensive action of labetalol in the pregnant patients. Supine systolic blood pressure fell by 0.38 (0.14-0.91) mm Hg per ng ml-1 of labetalol and diastolic by 0.36 (0.21- 1.14) mm Hg per ng ml-1 of labetalol. In the other two groups labetalol did not lower pressure sufficiently to allow modelling to be performed. 4 We conclude that pregnancy does not alter the clearance or volume of distribution of labetalol. Modelling techniques can be applied successfully to drug induced blood pressure changes during pregnancy." @default.
- W2080843360 created "2016-06-24" @default.
- W2080843360 creator A5031965850 @default.
- W2080843360 creator A5052343808 @default.
- W2080843360 creator A5065386001 @default.
- W2080843360 creator A5078176286 @default.
- W2080843360 creator A5088619412 @default.
- W2080843360 date "1983-04-01" @default.
- W2080843360 modified "2023-09-27" @default.
- W2080843360 title "Labetalol disposition and concentration-effect relationships during pregnancy." @default.
- W2080843360 cites W1525589992 @default.
- W2080843360 cites W1987544699 @default.
- W2080843360 cites W1992709483 @default.
- W2080843360 cites W1992902339 @default.
- W2080843360 cites W2010355194 @default.
- W2080843360 cites W2037953407 @default.
- W2080843360 cites W2043614247 @default.
- W2080843360 cites W2044649487 @default.
- W2080843360 cites W2056354457 @default.
- W2080843360 cites W2091563880 @default.
- W2080843360 cites W2093168605 @default.
- W2080843360 cites W2118671468 @default.
- W2080843360 cites W2124874141 @default.
- W2080843360 cites W2156060022 @default.
- W2080843360 cites W2324227497 @default.
- W2080843360 cites W2398970378 @default.
- W2080843360 cites W2400583996 @default.
- W2080843360 cites W2467955315 @default.
- W2080843360 doi "https://doi.org/10.1111/j.1365-2125.1983.tb01531.x" @default.
- W2080843360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1427790" @default.
- W2080843360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6849783" @default.
- W2080843360 hasPublicationYear "1983" @default.
- W2080843360 type Work @default.
- W2080843360 sameAs 2080843360 @default.
- W2080843360 citedByCount "46" @default.
- W2080843360 countsByYear W20808433602013 @default.
- W2080843360 countsByYear W20808433602014 @default.
- W2080843360 countsByYear W20808433602016 @default.
- W2080843360 countsByYear W20808433602018 @default.
- W2080843360 countsByYear W20808433602021 @default.
- W2080843360 countsByYear W20808433602022 @default.
- W2080843360 countsByYear W20808433602023 @default.
- W2080843360 crossrefType "journal-article" @default.
- W2080843360 hasAuthorship W2080843360A5031965850 @default.
- W2080843360 hasAuthorship W2080843360A5052343808 @default.
- W2080843360 hasAuthorship W2080843360A5065386001 @default.
- W2080843360 hasAuthorship W2080843360A5078176286 @default.
- W2080843360 hasAuthorship W2080843360A5088619412 @default.
- W2080843360 hasBestOaLocation W20808433602 @default.
- W2080843360 hasConcept C112705442 @default.
- W2080843360 hasConcept C125567185 @default.
- W2080843360 hasConcept C126322002 @default.
- W2080843360 hasConcept C139254425 @default.
- W2080843360 hasConcept C2777962398 @default.
- W2080843360 hasConcept C2779234561 @default.
- W2080843360 hasConcept C42219234 @default.
- W2080843360 hasConcept C54355233 @default.
- W2080843360 hasConcept C71924100 @default.
- W2080843360 hasConcept C84393581 @default.
- W2080843360 hasConcept C86803240 @default.
- W2080843360 hasConcept C98274493 @default.
- W2080843360 hasConceptScore W2080843360C112705442 @default.
- W2080843360 hasConceptScore W2080843360C125567185 @default.
- W2080843360 hasConceptScore W2080843360C126322002 @default.
- W2080843360 hasConceptScore W2080843360C139254425 @default.
- W2080843360 hasConceptScore W2080843360C2777962398 @default.
- W2080843360 hasConceptScore W2080843360C2779234561 @default.
- W2080843360 hasConceptScore W2080843360C42219234 @default.
- W2080843360 hasConceptScore W2080843360C54355233 @default.
- W2080843360 hasConceptScore W2080843360C71924100 @default.
- W2080843360 hasConceptScore W2080843360C84393581 @default.
- W2080843360 hasConceptScore W2080843360C86803240 @default.
- W2080843360 hasConceptScore W2080843360C98274493 @default.
- W2080843360 hasIssue "4" @default.
- W2080843360 hasLocation W20808433601 @default.
- W2080843360 hasLocation W20808433602 @default.
- W2080843360 hasLocation W20808433603 @default.
- W2080843360 hasLocation W20808433604 @default.
- W2080843360 hasOpenAccess W2080843360 @default.
- W2080843360 hasPrimaryLocation W20808433601 @default.
- W2080843360 hasRelatedWork W1977114496 @default.
- W2080843360 hasRelatedWork W1996081947 @default.
- W2080843360 hasRelatedWork W2008548381 @default.
- W2080843360 hasRelatedWork W2074231614 @default.
- W2080843360 hasRelatedWork W2202678366 @default.
- W2080843360 hasRelatedWork W2314643080 @default.
- W2080843360 hasRelatedWork W2418278928 @default.
- W2080843360 hasRelatedWork W2426772320 @default.
- W2080843360 hasRelatedWork W2428163555 @default.
- W2080843360 hasRelatedWork W1979168837 @default.
- W2080843360 hasVolume "15" @default.
- W2080843360 isParatext "false" @default.
- W2080843360 isRetracted "false" @default.
- W2080843360 magId "2080843360" @default.
- W2080843360 workType "article" @default.