FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080846031> ?p ?o ?g. }

• W2080846031 endingPage "174" @default.
• W2080846031 startingPage "170" @default.
• W2080846031 abstract "Psoriasis is a benign, chronic skin disease characterized by keratinocyte hyperproliferation and abnormal differentiation. Curcumin, a selective phosphorylase kinase inhibitor, is a natural phytochemical present in turmeric. Curcumin has been confirmed to have anti-inflammatory properties as well as the ability to inhibit proliferation and decrease the expression of pro-inflammatory cytokines in psoriatic keratinocytes. However, the pro-apoptotic effect of curcumin in keratinocytes remains unclear. In the present study, we investigated the effect of curcumin on apoptosis induction in TNF-α-treated HaCaT cells. These results show that curcumin exhibited a significant pro-apoptotic effect on HaCaT cells only in the presence of TNF-α and/or TRAIL. The pro-apoptotic effect of curcumin resulted from the increased expression of TRAIL-R1/R2 and the decreased expression of anti-apoptotic proteins. Our results indicate that both curcumin and TNF-α up-regulated the expression of TRAIL-R1/R2. In addition, the expression of anti-apoptotic proteins (IAP1, IAP2, Bcl-X(L)) was up-regulated by TNF-α but suppressed by curcumin in HaCaT cells. Because these proteins are regulated by NF-κB, we examined the role of curcumin in NF-κB activation. As expected, curcumin inhibited TNF-α-induced activation of NF-κB, including NF-κB-P65. Curcumin also inhibited the TNF-α-induced production of IL-6/IL-8 in HaCaT cells. These results imply that curcumin-induced apoptosis of HaCaT cells only occurs when TNF-α or/and TRAIL are present. Therefore, we believe that curcumin is able to reverse the anti-apoptotic function of TNF-α in HaCaT cells and thus expect curcumin to be successful in the treatment of psoriasis." @default.
• W2080846031 created "2016-06-24" @default.
• W2080846031 creator A5004698640 @default.
• W2080846031 creator A5011842932 @default.
• W2080846031 creator A5034976685 @default.
• W2080846031 creator A5048715243 @default.
• W2080846031 creator A5056132546 @default.
• W2080846031 date "2012-06-01" @default.
• W2080846031 modified "2023-10-01" @default.
• W2080846031 title "Curcumin induces apoptosis in tumor necrosis factor-alpha-treated HaCaT cells" @default.
• W2080846031 cites W1205185852 @default.
• W2080846031 cites W164058487 @default.
• W2080846031 cites W1991866963 @default.
• W2080846031 cites W1995177178 @default.
• W2080846031 cites W2003281193 @default.
• W2080846031 cites W2006018012 @default.
• W2080846031 cites W2010379558 @default.
• W2080846031 cites W2019108476 @default.
• W2080846031 cites W2024276500 @default.
• W2080846031 cites W2032906838 @default.
• W2080846031 cites W2048639599 @default.
• W2080846031 cites W2064379223 @default.
• W2080846031 cites W2072380594 @default.
• W2080846031 cites W2075300112 @default.
• W2080846031 cites W2112006696 @default.
• W2080846031 cites W2125799185 @default.
• W2080846031 cites W2127913359 @default.
• W2080846031 cites W2136466348 @default.
• W2080846031 cites W2146962477 @default.
• W2080846031 cites W2169972304 @default.
• W2080846031 cites W2171127879 @default.
• W2080846031 cites W2211426328 @default.
• W2080846031 cites W76644046 @default.
• W2080846031 doi "https://doi.org/10.1016/j.intimp.2012.03.025" @default.
• W2080846031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22498762" @default.
• W2080846031 hasPublicationYear "2012" @default.
• W2080846031 type Work @default.
• W2080846031 sameAs 2080846031 @default.
• W2080846031 citedByCount "37" @default.
• W2080846031 countsByYear W20808460312012 @default.
• W2080846031 countsByYear W20808460312013 @default.
• W2080846031 countsByYear W20808460312014 @default.
• W2080846031 countsByYear W20808460312015 @default.
• W2080846031 countsByYear W20808460312017 @default.
• W2080846031 countsByYear W20808460312018 @default.
• W2080846031 countsByYear W20808460312019 @default.
• W2080846031 countsByYear W20808460312020 @default.
• W2080846031 countsByYear W20808460312021 @default.
• W2080846031 countsByYear W20808460312022 @default.
• W2080846031 crossrefType "journal-article" @default.
• W2080846031 hasAuthorship W2080846031A5004698640 @default.
• W2080846031 hasAuthorship W2080846031A5011842932 @default.
• W2080846031 hasAuthorship W2080846031A5034976685 @default.
• W2080846031 hasAuthorship W2080846031A5048715243 @default.
• W2080846031 hasAuthorship W2080846031A5056132546 @default.
• W2080846031 hasConcept C118995209 @default.
• W2080846031 hasConcept C164027704 @default.
• W2080846031 hasConcept C17991360 @default.
• W2080846031 hasConcept C185592680 @default.
• W2080846031 hasConcept C190283241 @default.
• W2080846031 hasConcept C202751555 @default.
• W2080846031 hasConcept C203014093 @default.
• W2080846031 hasConcept C2776914184 @default.
• W2080846031 hasConcept C2777074287 @default.
• W2080846031 hasConcept C2778250585 @default.
• W2080846031 hasConcept C502942594 @default.
• W2080846031 hasConcept C55493867 @default.
• W2080846031 hasConcept C86803240 @default.
• W2080846031 hasConcept C95444343 @default.
• W2080846031 hasConcept C98274493 @default.
• W2080846031 hasConceptScore W2080846031C118995209 @default.
• W2080846031 hasConceptScore W2080846031C164027704 @default.
• W2080846031 hasConceptScore W2080846031C17991360 @default.
• W2080846031 hasConceptScore W2080846031C185592680 @default.
• W2080846031 hasConceptScore W2080846031C190283241 @default.
• W2080846031 hasConceptScore W2080846031C202751555 @default.
• W2080846031 hasConceptScore W2080846031C203014093 @default.
• W2080846031 hasConceptScore W2080846031C2776914184 @default.
• W2080846031 hasConceptScore W2080846031C2777074287 @default.
• W2080846031 hasConceptScore W2080846031C2778250585 @default.
• W2080846031 hasConceptScore W2080846031C502942594 @default.
• W2080846031 hasConceptScore W2080846031C55493867 @default.
• W2080846031 hasConceptScore W2080846031C86803240 @default.
• W2080846031 hasConceptScore W2080846031C95444343 @default.
• W2080846031 hasConceptScore W2080846031C98274493 @default.
• W2080846031 hasFunder F4320321001 @default.
• W2080846031 hasIssue "2" @default.
• W2080846031 hasLocation W20808460311 @default.
• W2080846031 hasLocation W20808460312 @default.
• W2080846031 hasOpenAccess W2080846031 @default.
• W2080846031 hasPrimaryLocation W20808460311 @default.
• W2080846031 hasRelatedWork W1590659816 @default.
• W2080846031 hasRelatedWork W1636401916 @default.
• W2080846031 hasRelatedWork W1999906187 @default.
• W2080846031 hasRelatedWork W2070440726 @default.
• W2080846031 hasRelatedWork W2352231646 @default.
• W2080846031 hasRelatedWork W2357221374 @default.
• W2080846031 hasRelatedWork W2378796802 @default.

• next