FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080851556> ?p ?o ?g. }

• W2080851556 endingPage "533" @default.
• W2080851556 startingPage "522" @default.
• W2080851556 abstract "We have investigated the mechanism of mitochondrial-nuclear crosstalk during cellular stress in mouse C2C12 myocytes. For this purpose, we used cells with reduced mitochondrial DNA (mtDNA) contents by ethidium bromide treatment or myocytes treated with known mitochondrial metabolic inhibitors, including carbonyl cyanide m-chlorophenylhydrazone (CCCP), antimycin, valinomycin and azide. Both genetic and metabolic stresses similarly affected mitochondrial membrane potential (Deltapsim) and electron transport-coupled ATP synthesis, which was also accompanied by an elevated steady-state cytosolic Ca2+ level ([Ca2+]i). The mitochondrial stress resulted in: (i) an enhanced expression of the sarcoplasmic reticular ryanodine receptor-1 (RyR-1), hence potentiating the Ca2+ release in response to its modulator, caffeine; (ii) enhanced levels of Ca2+-responsive factors calineurin, calcineurin-dependent NFATc (cytosolic counterpart of activated T-cell-specific nuclear factor) and c-Jun N-terminal kinase (JNK)-dependent ATF2 (activated transcription factor 2); (iii) reduced levels of transcription factor, NF-kappaB; and (iv) enhanced transcription of cytochrome oxidase Vb (COX Vb) subunit gene. These cellular changes, including the steady-state [Ca2+]i were normalized in genetically reverted cells which contain near-normal mtDNA levels. We propose that the mitochondria-to-nucleus stress signaling occurs through cytosolic [Ca2+]i changes, which are likely to be due to reduced ATP and Ca2+ efflux. Our results indicate that the mitochondrial stress signal affects a variety of cellular processes, in addition to mitochondrial membrane biogenesis." @default.
• W2080851556 created "2016-06-24" @default.
• W2080851556 creator A5010956002 @default.
• W2080851556 creator A5012090678 @default.
• W2080851556 creator A5025782791 @default.
• W2080851556 creator A5052486855 @default.
• W2080851556 creator A5055014981 @default.
• W2080851556 creator A5056241768 @default.
• W2080851556 creator A5063404637 @default.
• W2080851556 creator A5067529207 @default.
• W2080851556 date "1999-02-01" @default.
• W2080851556 modified "2023-10-17" @default.
• W2080851556 title "Retrograde Ca2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk" @default.
• W2080851556 cites W1481599856 @default.
• W2080851556 cites W1575912768 @default.
• W2080851556 cites W1590122376 @default.
• W2080851556 cites W1650401181 @default.
• W2080851556 cites W1666469474 @default.
• W2080851556 cites W1961319082 @default.
• W2080851556 cites W1963791094 @default.
• W2080851556 cites W1964469084 @default.
• W2080851556 cites W1967878986 @default.
• W2080851556 cites W1973851166 @default.
• W2080851556 cites W1977348907 @default.
• W2080851556 cites W1980166477 @default.
• W2080851556 cites W1981039973 @default.
• W2080851556 cites W1982439221 @default.
• W2080851556 cites W1983334891 @default.
• W2080851556 cites W1984665850 @default.
• W2080851556 cites W1984754431 @default.
• W2080851556 cites W1987733177 @default.
• W2080851556 cites W1989286153 @default.
• W2080851556 cites W1989378398 @default.
• W2080851556 cites W1992137920 @default.
• W2080851556 cites W2002662437 @default.
• W2080851556 cites W2010272081 @default.
• W2080851556 cites W2013056080 @default.
• W2080851556 cites W2017347785 @default.
• W2080851556 cites W2021869596 @default.
• W2080851556 cites W2028023732 @default.
• W2080851556 cites W2028527404 @default.
• W2080851556 cites W2036145275 @default.
• W2080851556 cites W2036717707 @default.
• W2080851556 cites W2039850925 @default.
• W2080851556 cites W2041512157 @default.
• W2080851556 cites W2057162464 @default.
• W2080851556 cites W2057931636 @default.
• W2080851556 cites W2067476421 @default.
• W2080851556 cites W2073706613 @default.
• W2080851556 cites W2073993982 @default.
• W2080851556 cites W2076503522 @default.
• W2080851556 cites W2077414996 @default.
• W2080851556 cites W2080027694 @default.
• W2080851556 cites W2080163146 @default.
• W2080851556 cites W2082918093 @default.
• W2080851556 cites W2084665287 @default.
• W2080851556 cites W2086486301 @default.
• W2080851556 cites W2092022390 @default.
• W2080851556 cites W2094821743 @default.
• W2080851556 cites W2099504760 @default.
• W2080851556 cites W2109323414 @default.
• W2080851556 cites W2112602336 @default.
• W2080851556 cites W2114969342 @default.
• W2080851556 cites W2122854426 @default.
• W2080851556 cites W2128525259 @default.
• W2080851556 cites W2129398678 @default.
• W2080851556 cites W2134692947 @default.
• W2080851556 cites W2136623476 @default.
• W2080851556 cites W2141174309 @default.
• W2080851556 cites W2156433522 @default.
• W2080851556 cites W2157502169 @default.
• W2080851556 cites W2159479663 @default.
• W2080851556 cites W2161760772 @default.
• W2080851556 cites W2162288115 @default.
• W2080851556 cites W2167335405 @default.
• W2080851556 cites W2170506039 @default.
• W2080851556 cites W2171240877 @default.
• W2080851556 cites W2173353469 @default.
• W2080851556 cites W2176573833 @default.
• W2080851556 cites W2328596111 @default.
• W2080851556 cites W4234999650 @default.
• W2080851556 cites W4249759827 @default.
• W2080851556 cites W4254119740 @default.
• W2080851556 cites W998554806 @default.
• W2080851556 doi "https://doi.org/10.1093/emboj/18.3.522" @default.
• W2080851556 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1171145" @default.
• W2080851556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9927412" @default.
• W2080851556 hasPublicationYear "1999" @default.
• W2080851556 type Work @default.
• W2080851556 sameAs 2080851556 @default.
• W2080851556 citedByCount "350" @default.
• W2080851556 countsByYear W20808515562012 @default.
• W2080851556 countsByYear W20808515562013 @default.
• W2080851556 countsByYear W20808515562014 @default.
• W2080851556 countsByYear W20808515562015 @default.
• W2080851556 countsByYear W20808515562016 @default.
• W2080851556 countsByYear W20808515562017 @default.
• W2080851556 countsByYear W20808515562018 @default.

• next