FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080852048> ?p ?o ?g. }

• W2080852048 endingPage "17458" @default.
• W2080852048 startingPage "17447" @default.
• W2080852048 abstract "Numerous transport processes occur between the two mitochondrial (mt) membranes due to the diverse functions and metabolic processes of the mt organelle. The metabolite and ion transport through the mt outer membrane (OM) is widely assumed to be mediated by the porin pore, whereas in the mt inner membrane (IM) specific carriers are responsible for transport processes. Here, we provide evidence by means of Blue Native (BN)-PAGE analysis, co-immunoprecipitation, and tandem affinity purification that the two mt OM proteins Om14p and Om45p associate with the porin pore. Porin molecules seem to assemble independently to build the core unit. A subpopulation of these core units interacts with Om14p and Om45p. With preparative tandem affinity purification followed by MS analysis, we could identify interaction partners of this OM complex, which are mainly localized within the mt IM and function as carriers for diverse molecules. We propose a model for the role of the two OM proteins in addressing the porin pore to bind to specific channels in the mt IM to facilitate transport of metabolites. Numerous transport processes occur between the two mitochondrial (mt) membranes due to the diverse functions and metabolic processes of the mt organelle. The metabolite and ion transport through the mt outer membrane (OM) is widely assumed to be mediated by the porin pore, whereas in the mt inner membrane (IM) specific carriers are responsible for transport processes. Here, we provide evidence by means of Blue Native (BN)-PAGE analysis, co-immunoprecipitation, and tandem affinity purification that the two mt OM proteins Om14p and Om45p associate with the porin pore. Porin molecules seem to assemble independently to build the core unit. A subpopulation of these core units interacts with Om14p and Om45p. With preparative tandem affinity purification followed by MS analysis, we could identify interaction partners of this OM complex, which are mainly localized within the mt IM and function as carriers for diverse molecules. We propose a model for the role of the two OM proteins in addressing the porin pore to bind to specific channels in the mt IM to facilitate transport of metabolites." @default.
• W2080852048 created "2016-06-24" @default.
• W2080852048 creator A5001250870 @default.
• W2080852048 creator A5006904583 @default.
• W2080852048 creator A5028608420 @default.
• W2080852048 creator A5048579827 @default.
• W2080852048 creator A5055624846 @default.
• W2080852048 creator A5060598459 @default.
• W2080852048 creator A5085180375 @default.
• W2080852048 date "2012-05-01" @default.
• W2080852048 modified "2023-10-17" @default.
• W2080852048 title "Saccharomyces cerevisiae Porin Pore Forms Complexes with Mitochondrial Outer Membrane Proteins Om14p and Om45p" @default.
• W2080852048 cites W142067924 @default.
• W2080852048 cites W1507851645 @default.
• W2080852048 cites W1542395301 @default.
• W2080852048 cites W1575542444 @default.
• W2080852048 cites W1579065797 @default.
• W2080852048 cites W1581059682 @default.
• W2080852048 cites W1948709514 @default.
• W2080852048 cites W1963530308 @default.
• W2080852048 cites W1964313477 @default.
• W2080852048 cites W1969515664 @default.
• W2080852048 cites W1972572583 @default.
• W2080852048 cites W1975998465 @default.
• W2080852048 cites W1978078069 @default.
• W2080852048 cites W1982926405 @default.
• W2080852048 cites W1984078838 @default.
• W2080852048 cites W1984788563 @default.
• W2080852048 cites W1986961470 @default.
• W2080852048 cites W1992293124 @default.
• W2080852048 cites W1992657834 @default.
• W2080852048 cites W1994297260 @default.
• W2080852048 cites W2001425543 @default.
• W2080852048 cites W2001660017 @default.
• W2080852048 cites W2004667717 @default.
• W2080852048 cites W2005984708 @default.
• W2080852048 cites W2006986579 @default.
• W2080852048 cites W2007552499 @default.
• W2080852048 cites W2009070900 @default.
• W2080852048 cites W2009461852 @default.
• W2080852048 cites W2011341002 @default.
• W2080852048 cites W2016853351 @default.
• W2080852048 cites W2021788902 @default.
• W2080852048 cites W2030349442 @default.
• W2080852048 cites W2031782316 @default.
• W2080852048 cites W2031972450 @default.
• W2080852048 cites W2034450620 @default.
• W2080852048 cites W2034826900 @default.
• W2080852048 cites W2037026478 @default.
• W2080852048 cites W2041293636 @default.
• W2080852048 cites W2042982552 @default.
• W2080852048 cites W2044218758 @default.
• W2080852048 cites W2054886960 @default.
• W2080852048 cites W2055699536 @default.
• W2080852048 cites W2057837015 @default.
• W2080852048 cites W2060189121 @default.
• W2080852048 cites W2062967090 @default.
• W2080852048 cites W2068240724 @default.
• W2080852048 cites W2074561332 @default.
• W2080852048 cites W2075920699 @default.
• W2080852048 cites W2080286047 @default.
• W2080852048 cites W2083243095 @default.
• W2080852048 cites W2085101416 @default.
• W2080852048 cites W2087384563 @default.
• W2080852048 cites W2088507374 @default.
• W2080852048 cites W2088613574 @default.
• W2080852048 cites W2090171916 @default.
• W2080852048 cites W2091074334 @default.
• W2080852048 cites W2095542431 @default.
• W2080852048 cites W2096457861 @default.
• W2080852048 cites W2097347505 @default.
• W2080852048 cites W2100837269 @default.
• W2080852048 cites W2103096171 @default.
• W2080852048 cites W2107664487 @default.
• W2080852048 cites W2108560778 @default.
• W2080852048 cites W2112310296 @default.
• W2080852048 cites W2124089572 @default.
• W2080852048 cites W2128659575 @default.
• W2080852048 cites W2128916568 @default.
• W2080852048 cites W2137451330 @default.
• W2080852048 cites W2141305651 @default.
• W2080852048 cites W2142849950 @default.
• W2080852048 cites W2149676146 @default.
• W2080852048 cites W2152231771 @default.
• W2080852048 cites W2153244115 @default.
• W2080852048 cites W2155890404 @default.
• W2080852048 cites W2160998060 @default.
• W2080852048 cites W2161284052 @default.
• W2080852048 cites W2163810841 @default.
• W2080852048 cites W2165046055 @default.
• W2080852048 cites W2165619409 @default.
• W2080852048 cites W2171991500 @default.
• W2080852048 cites W2287825996 @default.
• W2080852048 doi "https://doi.org/10.1074/jbc.m111.328328" @default.
• W2080852048 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3366824" @default.
• W2080852048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22461620" @default.
• W2080852048 hasPublicationYear "2012" @default.
• W2080852048 type Work @default.

• next