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• W2080852497 abstract "In mammalian cells, endocytosis of the fluid phase and glycosylphosphatidylinositol-anchored proteins (GPI-APs) forms GEECs (GPI-AP enriched early endosomal compartments) via an Arf1- and Cdc42-mediated, dynamin independent mechanism. Here we use four different fluorescently labeled probes and several markers in combination with quantitative kinetic assays, RNA interference and high resolution imaging to delineate major endocytic routes in Drosophila cultured cells. We find that the hallmarks of the pinocytic GEEC pathway are conserved in Drosophila and identify garz, the fly ortholog of the GTP exchange factor GBF1, as a novel component of this pathway. Live confocal and TIRF imaging reveals that a fraction of GBF1 GFP dynamically associates with ABD RFP (a sensor for activated Arf1 present on nascent pinosomes). Correspondingly, a GTP exchange mutant of GBF1 has altered ABD RFP localization in the evanescent field and is impaired in fluid phase uptake. Furthermore, GBF1 activation is required for the GEEC pathway even in the presence of Brefeldin A, implying that, like Arf1, it has a role in endocytosis that is separable from its role in secretion." @default.
• W2080852497 created "2016-06-24" @default.
• W2080852497 creator A5019103151 @default.
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• W2080852497 date "2009-08-26" @default.
• W2080852497 modified "2023-09-27" @default.
• W2080852497 title "Analysis of Endocytic Pathways in Drosophila Cells Reveals a Conserved Role for GBF1 in Internalization via GEECs" @default.
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• W2080852497 doi "https://doi.org/10.1371/journal.pone.0006768" @default.
• W2080852497 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2728541" @default.
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• W2080852497 hasPublicationYear "2009" @default.
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