FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080852992> ?p ?o ?g. }

• W2080852992 endingPage "68" @default.
• W2080852992 startingPage "53" @default.
• W2080852992 abstract "The chemical structure of 2-mercaptobenzimidazole (2-MBI), which is widely used as a rubber antioxidant, is partially similar to those of thiourea (TU) and ethylenethiourea (ETU), both potent thyrotoxic compounds. In order to determine the oral toxicity of 2-MBI, a 28-day repeated dose toxicity study in Wistar rats followed by observation over a 14-day recovery period was conducted at dose levels of 2, 10 and 50 mg/kg 2-MBI administered by gavage. No toxic deaths occurred due to 2-MBI treatment. Decreases of body weight gain and food consumption in the 50 mg/kg dose group were observed during the second half of the treatment period. In addition, hematological examination and serum biochemical tests revealed decreased white blood cells and hemoglobin and increased serum urea nitrogen, cholesterol, phospholipid, gamma-glutamyl transpeptidase and the Na+/K+ ratio in the 50 mg/kg dose group. Marked thyroid enlargement (to 10 fold the control weight), histopathologically associated with diffuse hyperplasia of follicles with decreased colloid and thickening of the fibrous capsule, was found. Reduction in thymus weight was also observed in a dose-dependent manner, without significant histopathological alteration. The non-observed effect level (NOEL) of 2-MBI in this gavage study was found to be less than 2 mg/kg/day based on the significant decrease in thymus weight in the 2 mg/kg 2-MBI treatment group. In an ancillary study, measurement of serum levels of T3, T4 and TSH, and thyroid weight after gavage treatment with 0.15 and 0.3 mmol/kg of three antithyroid compounds for 14 days revealed a more potent antithyroid effect for 2-MBI than for TU or ETU." @default.
• W2080852992 created "2016-06-24" @default.
• W2080852992 creator A5015956479 @default.
• W2080852992 creator A5016765346 @default.
• W2080852992 creator A5023805155 @default.
• W2080852992 creator A5029765609 @default.
• W2080852992 creator A5032709542 @default.
• W2080852992 creator A5040172517 @default.
• W2080852992 creator A5041515550 @default.
• W2080852992 creator A5048322272 @default.
• W2080852992 creator A5063381098 @default.
• W2080852992 creator A5073950608 @default.
• W2080852992 creator A5089344783 @default.
• W2080852992 creator A5091071220 @default.
• W2080852992 date "1998-01-01" @default.
• W2080852992 modified "2023-10-17" @default.
• W2080852992 title "Toxicity study of a rubber antioxidant, 2-mercaptobenzimidazole, by repeated oral administration to rats." @default.
• W2080852992 cites W132590113 @default.
• W2080852992 cites W1865924587 @default.
• W2080852992 cites W1973713220 @default.
• W2080852992 cites W1974761859 @default.
• W2080852992 cites W2007672028 @default.
• W2080852992 cites W2037098192 @default.
• W2080852992 cites W2042464457 @default.
• W2080852992 cites W2045583319 @default.
• W2080852992 cites W2045873882 @default.
• W2080852992 cites W2069709516 @default.
• W2080852992 cites W2072766736 @default.
• W2080852992 cites W2082188588 @default.
• W2080852992 cites W2111621105 @default.
• W2080852992 cites W2129429345 @default.
• W2080852992 cites W2132798984 @default.
• W2080852992 cites W2288219624 @default.
• W2080852992 doi "https://doi.org/10.2131/jts.23.53" @default.
• W2080852992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9513921" @default.
• W2080852992 hasPublicationYear "1998" @default.
• W2080852992 type Work @default.
• W2080852992 sameAs 2080852992 @default.
• W2080852992 citedByCount "18" @default.
• W2080852992 countsByYear W20808529922013 @default.
• W2080852992 countsByYear W20808529922014 @default.
• W2080852992 countsByYear W20808529922015 @default.
• W2080852992 countsByYear W20808529922017 @default.
• W2080852992 countsByYear W20808529922018 @default.
• W2080852992 countsByYear W20808529922020 @default.
• W2080852992 countsByYear W20808529922021 @default.
• W2080852992 countsByYear W20808529922022 @default.
• W2080852992 crossrefType "journal-article" @default.
• W2080852992 hasAuthorship W2080852992A5015956479 @default.
• W2080852992 hasAuthorship W2080852992A5016765346 @default.
• W2080852992 hasAuthorship W2080852992A5023805155 @default.
• W2080852992 hasAuthorship W2080852992A5029765609 @default.
• W2080852992 hasAuthorship W2080852992A5032709542 @default.
• W2080852992 hasAuthorship W2080852992A5040172517 @default.
• W2080852992 hasAuthorship W2080852992A5041515550 @default.
• W2080852992 hasAuthorship W2080852992A5048322272 @default.
• W2080852992 hasAuthorship W2080852992A5063381098 @default.
• W2080852992 hasAuthorship W2080852992A5073950608 @default.
• W2080852992 hasAuthorship W2080852992A5089344783 @default.
• W2080852992 hasAuthorship W2080852992A5091071220 @default.
• W2080852992 hasBestOaLocation W20808529921 @default.
• W2080852992 hasConcept C116263406 @default.
• W2080852992 hasConcept C126322002 @default.
• W2080852992 hasConcept C134018914 @default.
• W2080852992 hasConcept C185592680 @default.
• W2080852992 hasConcept C2777056448 @default.
• W2080852992 hasConcept C2777562237 @default.
• W2080852992 hasConcept C2778004101 @default.
• W2080852992 hasConcept C2778778583 @default.
• W2080852992 hasConcept C2778917026 @default.
• W2080852992 hasConcept C2780365088 @default.
• W2080852992 hasConcept C29730261 @default.
• W2080852992 hasConcept C526584372 @default.
• W2080852992 hasConcept C55493867 @default.
• W2080852992 hasConcept C59822182 @default.
• W2080852992 hasConcept C71924100 @default.
• W2080852992 hasConcept C86803240 @default.
• W2080852992 hasConcept C98274493 @default.
• W2080852992 hasConceptScore W2080852992C116263406 @default.
• W2080852992 hasConceptScore W2080852992C126322002 @default.
• W2080852992 hasConceptScore W2080852992C134018914 @default.
• W2080852992 hasConceptScore W2080852992C185592680 @default.
• W2080852992 hasConceptScore W2080852992C2777056448 @default.
• W2080852992 hasConceptScore W2080852992C2777562237 @default.
• W2080852992 hasConceptScore W2080852992C2778004101 @default.
• W2080852992 hasConceptScore W2080852992C2778778583 @default.
• W2080852992 hasConceptScore W2080852992C2778917026 @default.
• W2080852992 hasConceptScore W2080852992C2780365088 @default.
• W2080852992 hasConceptScore W2080852992C29730261 @default.
• W2080852992 hasConceptScore W2080852992C526584372 @default.
• W2080852992 hasConceptScore W2080852992C55493867 @default.
• W2080852992 hasConceptScore W2080852992C59822182 @default.
• W2080852992 hasConceptScore W2080852992C71924100 @default.
• W2080852992 hasConceptScore W2080852992C86803240 @default.
• W2080852992 hasConceptScore W2080852992C98274493 @default.
• W2080852992 hasIssue "1" @default.
• W2080852992 hasLocation W20808529921 @default.
• W2080852992 hasLocation W20808529922 @default.

• next