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• W2080853622 endingPage "95" @default.
• W2080853622 startingPage "90" @default.
• W2080853622 abstract "Assessment of sleep patterns in blind people demonstrates a high prevalence of sleep disorders. Our studies have shown that subjects with no conscious light perception (NPL) have a higher occurrence and more severe sleep disorders than those with some degree of light perception (LP). A detailed study of 49 blind individuals showed that those with NPL are likely to have free-running (FR) circadian rhythms (aMT6s, cortisol) including sleep. Non–24-hour (or FR) sleep-wake disorder, characterised by periods of good and bad sleep is a condition that may benefit from melatonin treatment. Melatonin has been administered to NPL subjects with FR circadian rhythms and compared with placebo (or the no-treatment baseline) sleep parameters improved. The results suggest that prior knowledge of the subject’s type of circadian rhythm, and timing of treatment in relation to the individual’s circadian phase, may improve the efficacy of melatonin." @default.
• W2080853622 created "2016-06-24" @default.
• W2080853622 creator A5006635271 @default.
• W2080853622 creator A5018500376 @default.
• W2080853622 creator A5063232801 @default.
• W2080853622 date "1999-01-01" @default.
• W2080853622 modified "2023-10-17" @default.
• W2080853622 title "Melatonin in Circadian Sleep Disorders in the Blind" @default.
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• W2080853622 doi "https://doi.org/10.1159/000014575" @default.
• W2080853622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10085469" @default.
• W2080853622 hasPublicationYear "1999" @default.
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