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- W2080853768 abstract "In the largest trial of its type carried out so far, the drug aminoglutethimide, which accomplishes a medical adrenalectomy, continues to appear to be effective for the treatment of postmenopausal women with disseminated breast cancer. Aminoglutethimide acts by inhibiting the enzymatic conversion of cholesterol to pregnenolone, an essential precursor of all steroid hormones. It has also been shown to inhibit the aromatase enzymes necessary for synthesis of estrogens from steroid precursors, thereby inhibiting estrogen synthesis in postmenopausal women. When 305 women with advanced breast cancer were given aminoglutethimide, the overall response rate was 26.5%, according to Trevor Powles, MB, Royal Marsden Hospital, Surrey, England. In 3.6% (11 patients), all evidence of disease disappeared (complete response), and in 22.9% (70 patients), some evidence of disease disappeared (partial response). disease was stabilized in another 12.7% (40 patients). The median duration of response was 14 months and was the same whether patients" @default.
- W2080853768 created "2016-06-24" @default.
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- W2080853768 date "1984-01-20" @default.
- W2080853768 modified "2023-09-26" @default.
- W2080853768 title "Breast cancer drug adrenalectomy 'passes'" @default.
- W2080853768 doi "https://doi.org/10.1001/jama.1984.03340270010009" @default.
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