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• W2080856936 abstract "This research was designed to investigate the protective effects of TSPN on steroid-induced avascular necrosis of the femoral head (ANFH) and the likely mechanisms of those effects. As an in vivo study, TSPN was shown to be protective against steroid-induced ANFH due to the upregulation of VEGF-A. Furthermore, TSPN attenuated the apoptosis of osteocytes and reduced the expression of Caspase-3 relative to the model group. As an in vitro study, TSPN exerted a concentration-dependent protective effect against apoptosis in MC3T3-E1 cells. Moreover, TSPN (at a dose of 100 μ g/mL) significantly reversed the dexamethasone-induced augmentation of Caspase-3 expression and activity. Therefore, our study demonstrated that TSPN had a protective effect against steroid-induced ANFH that was related to the upregulation of VEGF-A and the inhibition of apoptosis and Caspase-3 activation." @default.
• W2080856936 created "2016-06-24" @default.
• W2080856936 creator A5010016061 @default.
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• W2080856936 date "2015-01-01" @default.
• W2080856936 modified "2023-10-18" @default.
• W2080856936 title "Protective Effects of Total Saponins of Panax Notoginseng on Steroid-Induced Avascular Necrosis of the Femoral Head In Vivo and In Vitro" @default.
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• W2080856936 doi "https://doi.org/10.1155/2015/165679" @default.
• W2080856936 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4324945" @default.
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