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• W2080857061 endingPage "747" @default.
• W2080857061 startingPage "740" @default.
• W2080857061 abstract "Chronic alcohol abuse results in a variety of pathological effects including damage to the brain. The causes of alcohol-induced brain pathology are presently unclear. Several mechanisms of pathogenicity of chronic alcoholism have been proposed, including accumulation of DNA damage in the absence of repair, resulting in genomic instability and death of neurons. Genomic instability is a unified genetic mechanism leading to a variety of neurodegenerative disorders. Ethanol also likely interacts with various metabolic pathways, including one-carbon metabolism (OCM). OCM is critical for the synthesis of DNA precursors, essential for DNA repair, and as a methyl donor for various methylation events, including DNA methylation. Both DNA repair and DNA methylation are critical for maintaining genomic stability. In this review, we outline the role of DNA damage and DNA repair dysfunction in chronic alcohol-induced neurodegeneration." @default.
• W2080857061 created "2016-06-24" @default.
• W2080857061 creator A5033869317 @default.
• W2080857061 creator A5054883803 @default.
• W2080857061 creator A5071988751 @default.
• W2080857061 date "2012-07-01" @default.
• W2080857061 modified "2023-09-26" @default.
• W2080857061 title "DNA damage and neurotoxicity of chronic alcohol abuse" @default.
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