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- W2080859946 abstract "To determine whether or not the dimeric structure of neuropeptide Y (NPY) that is found in solution is necessary for its function, we investigated the effects of covalent dimerization on the structure and function of NPY using the carboxy-terminal fragment, NPY(12-36), in which residues 12 and 31 (located at both ends of α-helical region) were replaced by Cys residues. Among the three species (the parallel dimer, the anti-parallel dimer, and the intramolecularly cross-linked monomer) obtained by oxidation of the fragment, the anti-parallel dimer was predominant. NMR analysis showed that both parallel and anti-parallel dimers had α-helices similar to that of intact NPY, suggesting that covalent dimerization might have little effect on the helical structure. A binding assay with Y2 receptors on porcine hippocampal membranes revealed that the IC50value of the anti-parallel dimer was almost the same as that of NPY(13-36), which is known as a Y2-specific ligand. By contrast, the binding by the parallel dimer was weaker by more than one order of magnitude. Our results suggest that the formation of dimers of NPY is not essential for binding to the receptor." @default.
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- W2080859946 date "1997-12-01" @default.
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- W2080859946 title "Effects of Covalent Dimerization on the Structure and Function of the Carboxy-Terminal Fragment of Neuropeptide Y" @default.
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- W2080859946 doi "https://doi.org/10.1006/bbrc.1997.7661" @default.
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