Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080862998> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2080862998 abstract "In rat olfactory bulb, muscarinic and opioid receptor agonists stimulate basal adenylyl cyclase activity in a GTP-dependent and pertussis toxin-sensitive manner. However, in the present study, we show that in the same brain area activation of these receptors causes inhibition of adenylyl cyclase activity stimulated by Ca2+ and calmodulin (CaM) and by forskolin (FSK), two direct activators of the catalytic unit of the enzyme. The opioid and muscarinic inhibitions consist of a decrease of the maximal stimulation elicited by either CaM or FSK, without a change in the potency of these agents. [Leu5]-Enkephalin and selective delta- and mu-, but not kappa-, opioid receptor agonists inhibit the FSK stimulation of adenylyl cyclase activity with the same potencies displayed in stimulating basal enzyme activity. Similarly, the muscarinic inhibition of FSK-stimulated adenylyl cyclase activity shows agonist and antagonist sensitivities similar to those characterizing the muscarinic stimulation of basal enzyme activity. Fluoride stimulation of adenylyl cyclase is not affected by either carbachol or [Leu5]enkephalin. In vivo treatment of olfactory bulb with pertussis toxin prevents both opioid and muscarinic inhibition of Ca2+/CaM- and FSK-stimulated enzyme activities. These results indicate that in rat olfactory bulb delta- and mu-opioid receptors and muscarinic receptors, likely of the M4 subtype, can exert a dual effect on cyclic AMP formation by interacting with pertussis toxin-sensitive GTP-binding protein(s) and possibly by affecting different molecular forms of adenylyl cyclase." @default.
- W2080862998 created "2016-06-24" @default.
- W2080862998 creator A5000266425 @default.
- W2080862998 creator A5087267681 @default.
- W2080862998 date "2002-11-23" @default.
- W2080862998 modified "2023-09-26" @default.
- W2080862998 title "Activation of Opioid and Muscarinic Receptors Stimulates Basal Adenylyl Cyclase but Inhibits Ca2+/Calmodulin- and Forskolin-Stimulated Enzyme Activities in Rat Olfactory Bulb" @default.
- W2080862998 doi "https://doi.org/10.1046/j.1471-4159.1994.63010161.x" @default.
- W2080862998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8207425" @default.
- W2080862998 hasPublicationYear "2002" @default.
- W2080862998 type Work @default.
- W2080862998 sameAs 2080862998 @default.
- W2080862998 citedByCount "22" @default.
- W2080862998 crossrefType "journal-article" @default.
- W2080862998 hasAuthorship W2080862998A5000266425 @default.
- W2080862998 hasAuthorship W2080862998A5087267681 @default.
- W2080862998 hasConcept C126322002 @default.
- W2080862998 hasConcept C134018914 @default.
- W2080862998 hasConcept C170493617 @default.
- W2080862998 hasConcept C185592680 @default.
- W2080862998 hasConcept C24998067 @default.
- W2080862998 hasConcept C2751546 @default.
- W2080862998 hasConcept C2779178603 @default.
- W2080862998 hasConcept C2779276759 @default.
- W2080862998 hasConcept C33789571 @default.
- W2080862998 hasConcept C49773422 @default.
- W2080862998 hasConcept C55493867 @default.
- W2080862998 hasConcept C69101867 @default.
- W2080862998 hasConcept C71924100 @default.
- W2080862998 hasConcept C80631254 @default.
- W2080862998 hasConcept C86803240 @default.
- W2080862998 hasConceptScore W2080862998C126322002 @default.
- W2080862998 hasConceptScore W2080862998C134018914 @default.
- W2080862998 hasConceptScore W2080862998C170493617 @default.
- W2080862998 hasConceptScore W2080862998C185592680 @default.
- W2080862998 hasConceptScore W2080862998C24998067 @default.
- W2080862998 hasConceptScore W2080862998C2751546 @default.
- W2080862998 hasConceptScore W2080862998C2779178603 @default.
- W2080862998 hasConceptScore W2080862998C2779276759 @default.
- W2080862998 hasConceptScore W2080862998C33789571 @default.
- W2080862998 hasConceptScore W2080862998C49773422 @default.
- W2080862998 hasConceptScore W2080862998C55493867 @default.
- W2080862998 hasConceptScore W2080862998C69101867 @default.
- W2080862998 hasConceptScore W2080862998C71924100 @default.
- W2080862998 hasConceptScore W2080862998C80631254 @default.
- W2080862998 hasConceptScore W2080862998C86803240 @default.
- W2080862998 hasLocation W20808629981 @default.
- W2080862998 hasLocation W20808629982 @default.
- W2080862998 hasOpenAccess W2080862998 @default.
- W2080862998 hasPrimaryLocation W20808629981 @default.
- W2080862998 hasRelatedWork W123425600 @default.
- W2080862998 hasRelatedWork W1986767544 @default.
- W2080862998 hasRelatedWork W1991383916 @default.
- W2080862998 hasRelatedWork W2009650171 @default.
- W2080862998 hasRelatedWork W2026529611 @default.
- W2080862998 hasRelatedWork W2036154804 @default.
- W2080862998 hasRelatedWork W2045452477 @default.
- W2080862998 hasRelatedWork W2051312345 @default.
- W2080862998 hasRelatedWork W2066854425 @default.
- W2080862998 hasRelatedWork W2079521776 @default.
- W2080862998 isParatext "false" @default.
- W2080862998 isRetracted "false" @default.
- W2080862998 magId "2080862998" @default.
- W2080862998 workType "article" @default.