Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080866177> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2080866177 endingPage "99" @default.
- W2080866177 startingPage "93" @default.
- W2080866177 abstract "The aim of the present study was to develop and characterize the physiochemical properties of transdermal patches of 6‐Mercaptopturine (6‐MP) and evaluate the cytotoxicity, antitumor activity in Balb/c mice using Dalton's lymphoma ascites (DLA) as model cell lines, skin irritation and sensitization in mice and human subjects. 6‐MP was loaded into the patches according to pharmacokinetics properties of 6‐MP. Cytotoxicity was measured by exposing cell suspension to an increased concentration of drug from 50‐1000 ng/ml and the viable cell count was measured by the tryphan blue exclusion method. Results confirmed that 1000 ng/ml of 6‐MP was cytotoxic, and there was an increase in the life span (%ILS) by 71.0% with maximum survival time of 36±1days for 6‐MP transdermal patches, results were statistically significant (p <0.05) compared to untreated control, and anti‐tumor activity was very effective compared to the oral route. Patches did not show any sign of erythema, vesiculations or bullaous reaction, the mean cumulative skin irritation and adherence scoring for both animals and humans proved no irritation sensitization reaction scores were 0 and less than 1, good adherence was seen with score=0, with complete adherence to skin, without leaving any adhesive on skin with score=0 in human subjects. Transdermal patches showed 100% flatness, thickness 150±0.03 mm, good content uniformity, folding endurance (>500 foldings), tensile strength was 2.1 to 7.2 Newton's, elongation was 3–5%, patches were stylish, smooth, transparent, and flexible in appearance. The thumb tack test showed good adhesion, Velcro® protection jackets were suitable for study and served our purpose for licking, scratched and rubbing of applied patches." @default.
- W2080866177 created "2016-06-24" @default.
- W2080866177 creator A5010786269 @default.
- W2080866177 creator A5065536801 @default.
- W2080866177 date "2007-11-01" @default.
- W2080866177 modified "2023-09-26" @default.
- W2080866177 title "Pressure Sensitive Adhesive for 6‐Mercaptopurine Transdermal Delivery for Solid Tumor in Mice" @default.
- W2080866177 cites W1967490229 @default.
- W2080866177 cites W1983572926 @default.
- W2080866177 cites W2000342001 @default.
- W2080866177 cites W2028370579 @default.
- W2080866177 cites W2076449779 @default.
- W2080866177 cites W2151922213 @default.
- W2080866177 doi "https://doi.org/10.1080/10601320701683405" @default.
- W2080866177 hasPublicationYear "2007" @default.
- W2080866177 type Work @default.
- W2080866177 sameAs 2080866177 @default.
- W2080866177 citedByCount "1" @default.
- W2080866177 crossrefType "journal-article" @default.
- W2080866177 hasAuthorship W2080866177A5010786269 @default.
- W2080866177 hasAuthorship W2080866177A5065536801 @default.
- W2080866177 hasConcept C112705442 @default.
- W2080866177 hasConcept C141071460 @default.
- W2080866177 hasConcept C16005928 @default.
- W2080866177 hasConcept C185592680 @default.
- W2080866177 hasConcept C201253974 @default.
- W2080866177 hasConcept C203014093 @default.
- W2080866177 hasConcept C205679159 @default.
- W2080866177 hasConcept C2776217527 @default.
- W2080866177 hasConcept C2777063393 @default.
- W2080866177 hasConcept C2777937549 @default.
- W2080866177 hasConcept C2779121184 @default.
- W2080866177 hasConcept C3019129585 @default.
- W2080866177 hasConcept C71924100 @default.
- W2080866177 hasConcept C98274493 @default.
- W2080866177 hasConceptScore W2080866177C112705442 @default.
- W2080866177 hasConceptScore W2080866177C141071460 @default.
- W2080866177 hasConceptScore W2080866177C16005928 @default.
- W2080866177 hasConceptScore W2080866177C185592680 @default.
- W2080866177 hasConceptScore W2080866177C201253974 @default.
- W2080866177 hasConceptScore W2080866177C203014093 @default.
- W2080866177 hasConceptScore W2080866177C205679159 @default.
- W2080866177 hasConceptScore W2080866177C2776217527 @default.
- W2080866177 hasConceptScore W2080866177C2777063393 @default.
- W2080866177 hasConceptScore W2080866177C2777937549 @default.
- W2080866177 hasConceptScore W2080866177C2779121184 @default.
- W2080866177 hasConceptScore W2080866177C3019129585 @default.
- W2080866177 hasConceptScore W2080866177C71924100 @default.
- W2080866177 hasConceptScore W2080866177C98274493 @default.
- W2080866177 hasIssue "1" @default.
- W2080866177 hasLocation W20808661771 @default.
- W2080866177 hasOpenAccess W2080866177 @default.
- W2080866177 hasPrimaryLocation W20808661771 @default.
- W2080866177 hasRelatedWork W2007610906 @default.
- W2080866177 hasRelatedWork W2018691571 @default.
- W2080866177 hasRelatedWork W2072101865 @default.
- W2080866177 hasRelatedWork W2145460109 @default.
- W2080866177 hasRelatedWork W2355107996 @default.
- W2080866177 hasRelatedWork W2622251978 @default.
- W2080866177 hasRelatedWork W3089143512 @default.
- W2080866177 hasRelatedWork W4230419616 @default.
- W2080866177 hasRelatedWork W4293234387 @default.
- W2080866177 hasRelatedWork W582435074 @default.
- W2080866177 hasVolume "45" @default.
- W2080866177 isParatext "false" @default.
- W2080866177 isRetracted "false" @default.
- W2080866177 magId "2080866177" @default.
- W2080866177 workType "article" @default.