Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080867289> ?p ?o ?g. }
- W2080867289 endingPage "192" @default.
- W2080867289 startingPage "146" @default.
- W2080867289 abstract "The use of psychoactive drugs is a wide spread behaviour in human societies. The systematic use of a drug requires the establishment of different drug use-associated behaviours which need to be learned and controlled. However, controlled drug use may develop into compulsive drug use and addiction, a major psychiatric disorder with severe consequences for the individual and society. Here we review the role of the serotonergic (5-HT) system in the establishment of drug use-associated behaviours on the one hand and the transition and maintenance of addiction on the other hand for the drugs: cocaine, amphetamine, methamphetamine, MDMA (ecstasy), morphine/heroin, cannabis, alcohol, and nicotine. Results show a crucial, but distinct involvement of the 5-HT system in both processes with considerable overlap between psychostimulant and opioidergic drugs and alcohol. A new functional model suggests specific adaptations in the 5-HT system, which coincide with the establishment of controlled drug use-associated behaviours. These serotonergic adaptations render the nervous system susceptible to the transition to compulsive drug use behaviours and often overlap with genetic risk factors for addiction. Altogether we suggest a new trajectory by which serotonergic neuroadaptations induced by first drug exposure pave the way for the establishment of addiction." @default.
- W2080867289 created "2016-06-24" @default.
- W2080867289 creator A5072107327 @default.
- W2080867289 creator A5091840995 @default.
- W2080867289 date "2015-01-01" @default.
- W2080867289 modified "2023-10-14" @default.
- W2080867289 title "The role of serotonin in drug use and addiction" @default.
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