Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080868020> ?p ?o ?g. }
- W2080868020 endingPage "67" @default.
- W2080868020 startingPage "59" @default.
- W2080868020 abstract "High concentrations of glucose induce cardiomyocyte apoptosis, and contribute to diabetic cardiomyopathy. Relaxin-2 and relaxin-3 are two members of the relaxin peptide family that are cardioprotective. However, it remains unknown whether relaxin-2 or relaxin-3 can regulate apoptosis in high glucose treated-neonatal rat ventricular myocytes (NRVMs). In cultured NRVMs, 33 mmol/l high glucose (HG) increased apoptosis in a time-dependent manner. HG-increased the protein expression of cleaved caspase-8 and -9, two initiators of the extrinsic and intrinsic pathways of apoptosis, Caspase-3 was attenuated by human recombinant relaxin-2 (H2 relaxin) or relaxin-3 (H3 relaxin), indicating that H2 and H3 relaxin inhibited HG-induced apoptosis. Furthermore, endoplasmic reticulum stress (ERS) markers CHOP and caspase-12 were markedly increased in HG-treated NRVMs, leading to apoptosis; this effect was also effectively attenuated by H2 relaxin or H3 relaxin. Treatment of NRVMs with HG reduced autophagy which cannot be adjusted by H2 relaxin or H3 relaxin. In conclusion, HG-induced apoptosis in NRVMs was mediated, in part, by the activation of the extrinsic and intrinsic pathways of apoptosis and ERS, all inhibited by H2 relaxin or H3 relaxin." @default.
- W2080868020 created "2016-06-24" @default.
- W2080868020 creator A5001937247 @default.
- W2080868020 creator A5007999482 @default.
- W2080868020 creator A5017200569 @default.
- W2080868020 creator A5026447066 @default.
- W2080868020 creator A5037172649 @default.
- W2080868020 creator A5039629749 @default.
- W2080868020 creator A5046211215 @default.
- W2080868020 creator A5048010533 @default.
- W2080868020 creator A5049644175 @default.
- W2080868020 creator A5091620323 @default.
- W2080868020 date "2015-01-01" @default.
- W2080868020 modified "2023-09-27" @default.
- W2080868020 title "H2 and H3 relaxin inhibit high glucose-induced apoptosis in neonatal rat ventricular myocytes" @default.
- W2080868020 cites W1970433781 @default.
- W2080868020 cites W1976252854 @default.
- W2080868020 cites W1977767269 @default.
- W2080868020 cites W1985158738 @default.
- W2080868020 cites W1987443589 @default.
- W2080868020 cites W1992564227 @default.
- W2080868020 cites W1995572919 @default.
- W2080868020 cites W2006235680 @default.
- W2080868020 cites W2020765596 @default.
- W2080868020 cites W2028256617 @default.
- W2080868020 cites W2041626380 @default.
- W2080868020 cites W2046957125 @default.
- W2080868020 cites W2047690887 @default.
- W2080868020 cites W2057694501 @default.
- W2080868020 cites W2058525665 @default.
- W2080868020 cites W2063495408 @default.
- W2080868020 cites W2064950130 @default.
- W2080868020 cites W2068785830 @default.
- W2080868020 cites W2070290044 @default.
- W2080868020 cites W2073475311 @default.
- W2080868020 cites W2073767279 @default.
- W2080868020 cites W2076161537 @default.
- W2080868020 cites W2078818919 @default.
- W2080868020 cites W2087565932 @default.
- W2080868020 cites W2089122115 @default.
- W2080868020 cites W2089342328 @default.
- W2080868020 cites W2093807343 @default.
- W2080868020 cites W2106305106 @default.
- W2080868020 cites W2114648756 @default.
- W2080868020 cites W2122705632 @default.
- W2080868020 cites W2131666074 @default.
- W2080868020 cites W2133644385 @default.
- W2080868020 cites W2138742410 @default.
- W2080868020 cites W2145461802 @default.
- W2080868020 cites W2150262622 @default.
- W2080868020 cites W2153866356 @default.
- W2080868020 cites W2162969910 @default.
- W2080868020 cites W2167656141 @default.
- W2080868020 cites W4246726366 @default.
- W2080868020 doi "https://doi.org/10.1016/j.biochi.2014.11.004" @default.
- W2080868020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25446652" @default.
- W2080868020 hasPublicationYear "2015" @default.
- W2080868020 type Work @default.
- W2080868020 sameAs 2080868020 @default.
- W2080868020 citedByCount "22" @default.
- W2080868020 countsByYear W20808680202015 @default.
- W2080868020 countsByYear W20808680202016 @default.
- W2080868020 countsByYear W20808680202017 @default.
- W2080868020 countsByYear W20808680202018 @default.
- W2080868020 countsByYear W20808680202019 @default.
- W2080868020 countsByYear W20808680202020 @default.
- W2080868020 countsByYear W20808680202022 @default.
- W2080868020 countsByYear W20808680202023 @default.
- W2080868020 crossrefType "journal-article" @default.
- W2080868020 hasAuthorship W2080868020A5001937247 @default.
- W2080868020 hasAuthorship W2080868020A5007999482 @default.
- W2080868020 hasAuthorship W2080868020A5017200569 @default.
- W2080868020 hasAuthorship W2080868020A5026447066 @default.
- W2080868020 hasAuthorship W2080868020A5037172649 @default.
- W2080868020 hasAuthorship W2080868020A5039629749 @default.
- W2080868020 hasAuthorship W2080868020A5046211215 @default.
- W2080868020 hasAuthorship W2080868020A5048010533 @default.
- W2080868020 hasAuthorship W2080868020A5049644175 @default.
- W2080868020 hasAuthorship W2080868020A5091620323 @default.
- W2080868020 hasConcept C12519072 @default.
- W2080868020 hasConcept C126322002 @default.
- W2080868020 hasConcept C134018914 @default.
- W2080868020 hasConcept C185592680 @default.
- W2080868020 hasConcept C190283241 @default.
- W2080868020 hasConcept C207200792 @default.
- W2080868020 hasConcept C2777121736 @default.
- W2080868020 hasConcept C31573885 @default.
- W2080868020 hasConcept C55493867 @default.
- W2080868020 hasConcept C71315377 @default.
- W2080868020 hasConcept C71924100 @default.
- W2080868020 hasConcept C86803240 @default.
- W2080868020 hasConcept C95444343 @default.
- W2080868020 hasConceptScore W2080868020C12519072 @default.
- W2080868020 hasConceptScore W2080868020C126322002 @default.
- W2080868020 hasConceptScore W2080868020C134018914 @default.
- W2080868020 hasConceptScore W2080868020C185592680 @default.
- W2080868020 hasConceptScore W2080868020C190283241 @default.
- W2080868020 hasConceptScore W2080868020C207200792 @default.