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- W2080872485 abstract "Oocytes make histones much more slowly than do unfertilized eggs and embryos, although, in eggs, the overall rate of protein synthesis is only a little faster. The high rate of histone synthesis in eggs becomes established at the time of maturation of the oocyte, i.e., oocyte nucleus breakdown, but it is not dependent on nuclear breakdown. At all the earliest stages of development, histone synthesis is not coordinated with DNA synthesis. Enucleated oocytes and oocytes in the presence of actinomycin D were able to respond to progesterone by maturing and synthesizing histones at a stimulated rate. The acceleration of histone synthesis is, therefore, brought about by a post-transcriptional control mechanism capable of changing the relative amounts of different proteins made by the cell." @default.
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- W2080872485 date "1977-05-01" @default.
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- W2080872485 title "Changes in the rate of histone synthesis during oocyte maturation and very early development of Xenopus laevis" @default.
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- W2080872485 doi "https://doi.org/10.1016/0012-1606(77)90360-8" @default.
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