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- W2080878230 startingPage "1" @default.
- W2080878230 abstract "Gaining insight in likely disease emergence scenarios is critical to preventing such events from happening. Recent focus has been on emerging zoonoses and on identifying common patterns and drivers of emerging diseases. However, no overarching framework exists to integrate knowledge on all emerging infectious disease events. Here, we propose such a conceptual framework based on changes in the interplay of pathogens, hosts and environment that lead to the formation of novel disease patterns and pathogen genetic adjustment. We categorize infectious disease emergence events into three groups: (i) pathogens showing up in a novel host, ranging from spill-over, including zoonoses, to complete species jumps; (ii) mutant pathogens displaying novel traits in the same host, including an increase in virulence, antimicrobial resistance and host immune escape; and (iii) disease complexes emerging in a new geographic area, either through range expansion or through long distance jumps. Each of these categories is characterized by a typical set of drivers of emergence, matching pathogen trait profiles, disease ecology and transmission dynamics. Our framework may assist in disentangling and structuring the rapidly growing amount of available information on infectious diseases. Moreover, it may contribute to a better understanding of how human action changes disease landscapes globally." @default.
- W2080878230 created "2016-06-24" @default.
- W2080878230 creator A5022531656 @default.
- W2080878230 creator A5066673360 @default.
- W2080878230 creator A5078848017 @default.
- W2080878230 date "2013-01-01" @default.
- W2080878230 modified "2023-10-08" @default.
- W2080878230 title "Pathogen–host–environment interplay and disease emergence" @default.
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