Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080879454> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2080879454 endingPage "88" @default.
- W2080879454 startingPage "83" @default.
- W2080879454 abstract "ABSTRACT: Action potentials and voltage clamp-induced ionic currents were recorded in acutely isolated neonatal rabbit cardiac myocytes using the whole-cell voltage clamp technique. Time- and voltage-dependent Ca2+ currents in neonatal myocytes were elicited by depolarizations from a holding potential of —80 mV to various clamp potentials. The maximal measured inward Ca2+ current was 206 ± 10 pA (mean ± SEM, n = 51). The peak current occurred at a mean membrane potential of 7.8 ± 1.3 mV (n = 51). The Ca2+ current voltage relation was shifted 26 mV in the positive direction when the external Ca2+ concentration was increased 10-fold. Ca2+ current rundown was observed with a half-time of approximately 20 min. Cells dialyzed with solution containing the Ca2+ chelating agent, EGTA (0.04 mM), had action potential durations similar to those previously reported in papillary muscle. In contrast, a higher concentration of EGTA (14 mM) prolonged the action potential duration. Control of the cell internal ionic composition was achieved by dialysis of the cell with a time constant for Na+ ions of 1.2 to 2.6 min. Tetrodotoxin (10 μM), included in some experiments to block Ca2+ entry via Na+ channels, was shown to be more than 98% effective. These results characterize the whole-cell voltage clamp technique as applied to immature heart cells." @default.
- W2080879454 created "2016-06-24" @default.
- W2080879454 creator A5037820914 @default.
- W2080879454 creator A5038750164 @default.
- W2080879454 creator A5050791253 @default.
- W2080879454 creator A5077442786 @default.
- W2080879454 date "1991-07-01" @default.
- W2080879454 modified "2023-10-18" @default.
- W2080879454 title "Calcium Current Measurements in Acutely Isolated Neonatal Cardiac Myocytes" @default.
- W2080879454 doi "https://doi.org/10.1203/00006450-199107000-00017" @default.
- W2080879454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1891283" @default.
- W2080879454 hasPublicationYear "1991" @default.
- W2080879454 type Work @default.
- W2080879454 sameAs 2080879454 @default.
- W2080879454 citedByCount "9" @default.
- W2080879454 countsByYear W20808794542014 @default.
- W2080879454 countsByYear W20808794542018 @default.
- W2080879454 crossrefType "journal-article" @default.
- W2080879454 hasAuthorship W2080879454A5037820914 @default.
- W2080879454 hasAuthorship W2080879454A5038750164 @default.
- W2080879454 hasAuthorship W2080879454A5050791253 @default.
- W2080879454 hasAuthorship W2080879454A5077442786 @default.
- W2080879454 hasBestOaLocation W20808794541 @default.
- W2080879454 hasConcept C100837961 @default.
- W2080879454 hasConcept C105702510 @default.
- W2080879454 hasConcept C12554922 @default.
- W2080879454 hasConcept C126322002 @default.
- W2080879454 hasConcept C127413603 @default.
- W2080879454 hasConcept C147944092 @default.
- W2080879454 hasConcept C158494493 @default.
- W2080879454 hasConcept C178790620 @default.
- W2080879454 hasConcept C181911157 @default.
- W2080879454 hasConcept C185263204 @default.
- W2080879454 hasConcept C185592680 @default.
- W2080879454 hasConcept C207200792 @default.
- W2080879454 hasConcept C2776161997 @default.
- W2080879454 hasConcept C2776741303 @default.
- W2080879454 hasConcept C2777658833 @default.
- W2080879454 hasConcept C519063684 @default.
- W2080879454 hasConcept C71924100 @default.
- W2080879454 hasConcept C78519656 @default.
- W2080879454 hasConcept C84111939 @default.
- W2080879454 hasConcept C86803240 @default.
- W2080879454 hasConceptScore W2080879454C100837961 @default.
- W2080879454 hasConceptScore W2080879454C105702510 @default.
- W2080879454 hasConceptScore W2080879454C12554922 @default.
- W2080879454 hasConceptScore W2080879454C126322002 @default.
- W2080879454 hasConceptScore W2080879454C127413603 @default.
- W2080879454 hasConceptScore W2080879454C147944092 @default.
- W2080879454 hasConceptScore W2080879454C158494493 @default.
- W2080879454 hasConceptScore W2080879454C178790620 @default.
- W2080879454 hasConceptScore W2080879454C181911157 @default.
- W2080879454 hasConceptScore W2080879454C185263204 @default.
- W2080879454 hasConceptScore W2080879454C185592680 @default.
- W2080879454 hasConceptScore W2080879454C207200792 @default.
- W2080879454 hasConceptScore W2080879454C2776161997 @default.
- W2080879454 hasConceptScore W2080879454C2776741303 @default.
- W2080879454 hasConceptScore W2080879454C2777658833 @default.
- W2080879454 hasConceptScore W2080879454C519063684 @default.
- W2080879454 hasConceptScore W2080879454C71924100 @default.
- W2080879454 hasConceptScore W2080879454C78519656 @default.
- W2080879454 hasConceptScore W2080879454C84111939 @default.
- W2080879454 hasConceptScore W2080879454C86803240 @default.
- W2080879454 hasIssue "1" @default.
- W2080879454 hasLocation W20808794541 @default.
- W2080879454 hasLocation W20808794542 @default.
- W2080879454 hasOpenAccess W2080879454 @default.
- W2080879454 hasPrimaryLocation W20808794541 @default.
- W2080879454 hasRelatedWork W1976128502 @default.
- W2080879454 hasRelatedWork W1986929842 @default.
- W2080879454 hasRelatedWork W1993373176 @default.
- W2080879454 hasRelatedWork W2016491335 @default.
- W2080879454 hasRelatedWork W2055830121 @default.
- W2080879454 hasRelatedWork W2073090149 @default.
- W2080879454 hasRelatedWork W2078280030 @default.
- W2080879454 hasRelatedWork W2080786078 @default.
- W2080879454 hasRelatedWork W2080879454 @default.
- W2080879454 hasRelatedWork W4238409592 @default.
- W2080879454 hasVolume "30" @default.
- W2080879454 isParatext "false" @default.
- W2080879454 isRetracted "false" @default.
- W2080879454 magId "2080879454" @default.
- W2080879454 workType "article" @default.