Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080879903> ?p ?o ?g. }
- W2080879903 endingPage "e61071" @default.
- W2080879903 startingPage "e61071" @default.
- W2080879903 abstract "Several markers identify cancer stem cell-like populations, but little is known about the functional roles of stem cell surface receptors in tumor progression. Here, we show that the endothelial protein C receptor (EPCR), a stem cell marker in hematopoietic, neuronal and epithelial cells, is crucial for breast cancer growth in the orthotopic microenvironment of the mammary gland. Mice with a hypomorphic allele of EPCR show reduced tumor growth in the PyMT-model of spontaneous breast cancer development and deletion of EPCR in established PyMT tumor cells significantly attenuates transplanted tumor take and growth. We find expansion of EPCR+ cancer stem cell-like populations in aggressive, mammary fat pad-enhanced human triple negative breast cancer cells. In this model, EPCR-expressing cells have markedly increased mammosphere- and tumor-cell initiating activity compared to another stable progenitor-like subpopulation present at comparable frequency. We show that receptor blocking antibodies to EPCR specifically attenuate in vivo tumor growth initiated by either EPCR+ cells or the heterogenous mixture of EPCR+ and EPCR- cells. Furthermore, we have identified tumor associated macrophages as a major source for recognized ligands of EPCR, suggesting a novel mechanism by which cancer stem cell-like populations are regulated by innate immune cells in the tumor microenvironment." @default.
- W2080879903 created "2016-06-24" @default.
- W2080879903 creator A5003239045 @default.
- W2080879903 creator A5005286957 @default.
- W2080879903 creator A5044188173 @default.
- W2080879903 creator A5050466082 @default.
- W2080879903 creator A5050874021 @default.
- W2080879903 creator A5056607779 @default.
- W2080879903 creator A5075556432 @default.
- W2080879903 creator A5078439459 @default.
- W2080879903 creator A5087307957 @default.
- W2080879903 date "2013-04-09" @default.
- W2080879903 modified "2023-10-06" @default.
- W2080879903 title "Endothelial Protein C Receptor Function in Murine and Human Breast Cancer Development" @default.
- W2080879903 cites W1509894190 @default.
- W2080879903 cites W1561840795 @default.
- W2080879903 cites W1607367030 @default.
- W2080879903 cites W172709144 @default.
- W2080879903 cites W1805074460 @default.
- W2080879903 cites W1966693902 @default.
- W2080879903 cites W1980714336 @default.
- W2080879903 cites W1987012261 @default.
- W2080879903 cites W1998575929 @default.
- W2080879903 cites W2000985786 @default.
- W2080879903 cites W2001627351 @default.
- W2080879903 cites W2004471993 @default.
- W2080879903 cites W2014691022 @default.
- W2080879903 cites W2015617213 @default.
- W2080879903 cites W2020363094 @default.
- W2080879903 cites W2022121849 @default.
- W2080879903 cites W2023316892 @default.
- W2080879903 cites W2023427658 @default.
- W2080879903 cites W2025268465 @default.
- W2080879903 cites W2026410953 @default.
- W2080879903 cites W2026803473 @default.
- W2080879903 cites W2031770999 @default.
- W2080879903 cites W2042082129 @default.
- W2080879903 cites W2047688072 @default.
- W2080879903 cites W2055792439 @default.
- W2080879903 cites W2058648826 @default.
- W2080879903 cites W2062393641 @default.
- W2080879903 cites W2063754581 @default.
- W2080879903 cites W2065227956 @default.
- W2080879903 cites W2067716683 @default.
- W2080879903 cites W2068655393 @default.
- W2080879903 cites W2068773189 @default.
- W2080879903 cites W2073759231 @default.
- W2080879903 cites W2073933974 @default.
- W2080879903 cites W2074016597 @default.
- W2080879903 cites W2078104401 @default.
- W2080879903 cites W2079428292 @default.
- W2080879903 cites W2083884362 @default.
- W2080879903 cites W2101137688 @default.
- W2080879903 cites W2104104624 @default.
- W2080879903 cites W2108883574 @default.
- W2080879903 cites W2111449140 @default.
- W2080879903 cites W2118186012 @default.
- W2080879903 cites W2119739306 @default.
- W2080879903 cites W2125418204 @default.
- W2080879903 cites W2128738080 @default.
- W2080879903 cites W2129375080 @default.
- W2080879903 cites W2132472016 @default.
- W2080879903 cites W2135552434 @default.
- W2080879903 cites W2136178883 @default.
- W2080879903 cites W2139005650 @default.
- W2080879903 cites W2143856136 @default.
- W2080879903 cites W2148127512 @default.
- W2080879903 cites W2151011478 @default.
- W2080879903 cites W2151948621 @default.
- W2080879903 cites W2160217779 @default.
- W2080879903 cites W2160928966 @default.
- W2080879903 cites W2161968393 @default.
- W2080879903 cites W2162744498 @default.
- W2080879903 cites W2416980172 @default.
- W2080879903 doi "https://doi.org/10.1371/journal.pone.0061071" @default.
- W2080879903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3621887" @default.
- W2080879903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23593394" @default.
- W2080879903 hasPublicationYear "2013" @default.
- W2080879903 type Work @default.
- W2080879903 sameAs 2080879903 @default.
- W2080879903 citedByCount "55" @default.
- W2080879903 countsByYear W20808799032013 @default.
- W2080879903 countsByYear W20808799032014 @default.
- W2080879903 countsByYear W20808799032015 @default.
- W2080879903 countsByYear W20808799032016 @default.
- W2080879903 countsByYear W20808799032017 @default.
- W2080879903 countsByYear W20808799032018 @default.
- W2080879903 countsByYear W20808799032019 @default.
- W2080879903 countsByYear W20808799032020 @default.
- W2080879903 countsByYear W20808799032021 @default.
- W2080879903 countsByYear W20808799032022 @default.
- W2080879903 countsByYear W20808799032023 @default.
- W2080879903 crossrefType "journal-article" @default.
- W2080879903 hasAuthorship W2080879903A5003239045 @default.
- W2080879903 hasAuthorship W2080879903A5005286957 @default.
- W2080879903 hasAuthorship W2080879903A5044188173 @default.
- W2080879903 hasAuthorship W2080879903A5050466082 @default.
- W2080879903 hasAuthorship W2080879903A5050874021 @default.