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- W2080882173 abstract "The effect of morphine on the ipsilateral hindleg flexor reflex evoked by radiant heat or by electric stimulation of the paw was studied in rabbits. Morphine was injected systemically into the whole ventricular system and into restricted parts of it. Morphine, when administered intraventricularly at very low doses, induced reflex inhibition which was comparable to the effect obtained when the drug was applied systemically. By means of radioassay of 14C-labelled morphine, it was shown that a spinal site of action is not involved in this effect. Administration of morphine to restricted anterior parts of the ventricular system (consisting of the 3rd ventricle and the lateral ventricles) was ineffective whereas morphine injected into the 4th ventricle induced a strong reflex inhibition. Intracisternal injection was ineffective when the 4th ventricle was closed by a plug. Reflex inhibition induced by systemic morphine administration was reversed when levallorphan was injected intraventricularly or systemically. Experiments in which the concentration of 3H-levallorphan in the spinal cord was studied, showed that also after systemic morphine administration a spinal site of action is, if at all, of little importance. From these results it is concluded that a very strong morphine-induced reflex inhibition originates from brain structures easily reached by the drug from the fossa rhomboidea." @default.
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- W2080882173 date "1973-02-01" @default.
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- W2080882173 title "Differentiation between spinal and supraspinal sites of action of morphine when inhibiting the hindleg flexor reflex in rabbits" @default.
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- W2080882173 doi "https://doi.org/10.1016/0028-3908(73)90081-6" @default.
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