Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080882324> ?p ?o ?g. }
- W2080882324 endingPage "11" @default.
- W2080882324 startingPage "1" @default.
- W2080882324 abstract "Asbestos-induced mutagenicity in the lung may involve reactive oxygen/nitrogen species (ROS/RNS) released by alveolar macrophages. With the aim of proposing an alternative in vitro mutagenesis test, a coculture system of rat alveolar macrophages (NR8383) and transgenic Big Blue Rat2 embryonic fibroblasts was developed and tested with a crocidolite sample. Crocidolite exposure induced no detectable increase in ROS production from NR8383, contrasting with the oxidative burst that occurred following a brief exposure (1 hour) to zymosan, a known macrophage activator. In separated cocultures, crocidolite and zymosan induced different changes in the gene expressions involved in cellular inflammation in NR8383 and Big Blue. In particular, both particles induced up-regulation of iNOS expression in Big Blue, suggesting the formation of potentially genotoxic nitrogen species. However, crocidolite exposure in separated or mixed cocultures induced no mutagenic effects whereas an increase in Big Blue mutants was detected after exposure to zymosan in mixed cocultures. NR8383 activation by crocidolite is probably insufficient to induce in vitro mutagenic events. The mutagenesis assay based on the coculture of NR8383 and Big Blue cannot be used as an alternative in vitro method to assess the mutagenic properties of asbestos fibres." @default.
- W2080882324 created "2016-06-24" @default.
- W2080882324 creator A5007963998 @default.
- W2080882324 creator A5034028877 @default.
- W2080882324 creator A5037839606 @default.
- W2080882324 creator A5042633967 @default.
- W2080882324 creator A5044647326 @default.
- W2080882324 creator A5055744033 @default.
- W2080882324 creator A5072841617 @default.
- W2080882324 creator A5072990438 @default.
- W2080882324 creator A5076571677 @default.
- W2080882324 date "2010-01-01" @default.
- W2080882324 modified "2023-09-23" @default.
- W2080882324 title "In Vitro Study of Mutagenesis Induced by Crocidolite-Exposed Alveolar Macrophages NR8383 in Cocultured Big Blue Rat2 Embryonic Fibroblasts" @default.
- W2080882324 cites W1532131452 @default.
- W2080882324 cites W1970063776 @default.
- W2080882324 cites W1976665372 @default.
- W2080882324 cites W1981158444 @default.
- W2080882324 cites W1987580232 @default.
- W2080882324 cites W1990518082 @default.
- W2080882324 cites W1992157444 @default.
- W2080882324 cites W1993348692 @default.
- W2080882324 cites W1994019122 @default.
- W2080882324 cites W1994518218 @default.
- W2080882324 cites W1996435164 @default.
- W2080882324 cites W2000524843 @default.
- W2080882324 cites W2008269010 @default.
- W2080882324 cites W2011880710 @default.
- W2080882324 cites W2011952213 @default.
- W2080882324 cites W2014084783 @default.
- W2080882324 cites W2017522812 @default.
- W2080882324 cites W2022535202 @default.
- W2080882324 cites W2027310441 @default.
- W2080882324 cites W2030261566 @default.
- W2080882324 cites W2032824681 @default.
- W2080882324 cites W2033935749 @default.
- W2080882324 cites W2038132277 @default.
- W2080882324 cites W2047455844 @default.
- W2080882324 cites W2055444768 @default.
- W2080882324 cites W2057122622 @default.
- W2080882324 cites W2057707751 @default.
- W2080882324 cites W2057810394 @default.
- W2080882324 cites W2064421085 @default.
- W2080882324 cites W2085991989 @default.
- W2080882324 cites W2091903932 @default.
- W2080882324 cites W2093847925 @default.
- W2080882324 cites W2094090874 @default.
- W2080882324 cites W2101396327 @default.
- W2080882324 cites W2115217222 @default.
- W2080882324 cites W2124529236 @default.
- W2080882324 cites W2131910049 @default.
- W2080882324 cites W2161862142 @default.
- W2080882324 cites W2318286695 @default.
- W2080882324 cites W4211187922 @default.
- W2080882324 doi "https://doi.org/10.1155/2010/323828" @default.
- W2080882324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2901601" @default.
- W2080882324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20628587" @default.
- W2080882324 hasPublicationYear "2010" @default.
- W2080882324 type Work @default.
- W2080882324 sameAs 2080882324 @default.
- W2080882324 citedByCount "5" @default.
- W2080882324 countsByYear W20808823242016 @default.
- W2080882324 countsByYear W20808823242018 @default.
- W2080882324 countsByYear W20808823242019 @default.
- W2080882324 countsByYear W20808823242022 @default.
- W2080882324 crossrefType "journal-article" @default.
- W2080882324 hasAuthorship W2080882324A5007963998 @default.
- W2080882324 hasAuthorship W2080882324A5034028877 @default.
- W2080882324 hasAuthorship W2080882324A5037839606 @default.
- W2080882324 hasAuthorship W2080882324A5042633967 @default.
- W2080882324 hasAuthorship W2080882324A5044647326 @default.
- W2080882324 hasAuthorship W2080882324A5055744033 @default.
- W2080882324 hasAuthorship W2080882324A5072841617 @default.
- W2080882324 hasAuthorship W2080882324A5072990438 @default.
- W2080882324 hasAuthorship W2080882324A5076571677 @default.
- W2080882324 hasBestOaLocation W20808823241 @default.
- W2080882324 hasConcept C153911025 @default.
- W2080882324 hasConcept C185592680 @default.
- W2080882324 hasConcept C202751555 @default.
- W2080882324 hasConcept C2778012055 @default.
- W2080882324 hasConcept C2778870864 @default.
- W2080882324 hasConcept C2779244956 @default.
- W2080882324 hasConcept C55493867 @default.
- W2080882324 hasConcept C86803240 @default.
- W2080882324 hasConcept C95444343 @default.
- W2080882324 hasConceptScore W2080882324C153911025 @default.
- W2080882324 hasConceptScore W2080882324C185592680 @default.
- W2080882324 hasConceptScore W2080882324C202751555 @default.
- W2080882324 hasConceptScore W2080882324C2778012055 @default.
- W2080882324 hasConceptScore W2080882324C2778870864 @default.
- W2080882324 hasConceptScore W2080882324C2779244956 @default.
- W2080882324 hasConceptScore W2080882324C55493867 @default.
- W2080882324 hasConceptScore W2080882324C86803240 @default.
- W2080882324 hasConceptScore W2080882324C95444343 @default.
- W2080882324 hasLocation W20808823241 @default.
- W2080882324 hasLocation W20808823242 @default.
- W2080882324 hasLocation W20808823243 @default.
- W2080882324 hasLocation W20808823244 @default.