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- W2080882504 abstract "Abstract Integrins are heterodimers consisting of non‐covalently associated alpha and beta subunits. They mediate adherence of normal and tumour cells to the extracellular matrix, a property which is essential for migration of neoplastic astrocytes as they invade into the normal brain parenchyma. Flow cytometry and immunocytochemical analysis of cultured cells derived from 10 gliomas (1 pilocytic astrocytoma, 1 astrocytoma, 1 oligoastrocytoma, 1 anaplastic oligoastrocytoma, 4 anaplastic astrocytomas and 2 glioblastoma multiforme) revealed that the β 1 integrin subunit was generally expressed more strongly than α 4 or α v integrin subunits. Subsequent studies with function‐blocking antibodies against the β 1 subunit inhibited adhesion, motility and invasion of the gliomas in vitro, to varying degrees, on all extracellular matrix substrates investigated (laminin, collagen type IV, fibronectin and vitronectin), the inhibition by β 1 subunit was greatest on collagen type IV. These studies therefore substantiate the case for a role of the β 1 integrin subunit in neoplastic glial cell invasion of the brain." @default.
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- W2080882504 date "1999-08-01" @default.
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- W2080882504 title "The role of integrin receptors in aspects of glioma invasion <i>in vitro</i>" @default.
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- W2080882504 doi "https://doi.org/10.1016/s0736-5748(99)00051-9" @default.
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