FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080883955> ?p ?o ?g. }

• W2080883955 endingPage "73" @default.
• W2080883955 startingPage "65" @default.
• W2080883955 abstract "We compared the relative potencies of sinorphan and retorphan, the S- and R-enantiomers of acetorphan a potent inhibitor of enkephalinase (EC 3.4.34.11), to inhibit membrane metalloendopeptidase in vivo and to protect exogenous and endogenous ANF after oral administration. In mice, sinorphan was 2-3 fold as potent as retorphan in inhibiting the specific in vivo binding of [3H]acetorphan to kidney enkephalinase. The same potency ratio was found for the enhancement of trichloroacetic acid-precipitated radioactivity in kidneys of mice that had received 125I-ANF, which is used as a test for the protection of the hormone against inactivation in vivo. In nine healthy human volunteers who had received a low oral dosage of sinorphan or retorphan in a double-blind, placebo-controlled, randomized trial, sinorphan was also 2-3 fold more potent than retorphan in inhibiting plasma enkephalinase activity. These effects were accompanied by a related rise in plasma ANF immunoreactivity, which also reflected the difference in the effectiveness of the two compounds. Sinorphan was also more potent than retorphan in enhancing urinary cyclic GMP excretion and sodium excretion in five of these subjects. These data indicate that, in humans as in rodents, enkephalinase plays a crucial role in the inactivation of ANF, its partial inhibition in vivo being accompanied by a significant protection of the exogenous or endogenous hormone as well as by typical ANF-like responses. Thus orally administered sinorphan appears to be a promising compound for therapeutic use in cardiovascular and renal diseases in which ANF has been postulated to exert beneficial effects." @default.
• W2080883955 created "2016-06-24" @default.
• W2080883955 creator A5019499764 @default.
• W2080883955 creator A5020116197 @default.
• W2080883955 creator A5022326769 @default.
• W2080883955 creator A5027713819 @default.
• W2080883955 creator A5036202603 @default.
• W2080883955 creator A5038230315 @default.
• W2080883955 creator A5039382619 @default.
• W2080883955 creator A5044543101 @default.
• W2080883955 creator A5045398922 @default.
• W2080883955 creator A5055492584 @default.
• W2080883955 creator A5072966767 @default.
• W2080883955 date "1990-04-01" @default.
• W2080883955 modified "2023-10-16" @default.
• W2080883955 title "Stereoselective protection of exogenous and endogenous atrial natriuretic factor by enkephalinase inhibitors in mice and humans" @default.
• W2080883955 cites W1963562403 @default.
• W2080883955 cites W1979435301 @default.
• W2080883955 cites W1982415059 @default.
• W2080883955 cites W2001871700 @default.
• W2080883955 cites W2020266348 @default.
• W2080883955 cites W2024857020 @default.
• W2080883955 cites W2027466789 @default.
• W2080883955 cites W2029300132 @default.
• W2080883955 cites W2030340858 @default.
• W2080883955 cites W2032827384 @default.
• W2080883955 cites W2034351494 @default.
• W2080883955 cites W2038761203 @default.
• W2080883955 cites W2039565232 @default.
• W2080883955 cites W2047025106 @default.
• W2080883955 cites W2076432885 @default.
• W2080883955 cites W2087339845 @default.
• W2080883955 cites W2087977257 @default.
• W2080883955 cites W2099601233 @default.
• W2080883955 cites W2100515103 @default.
• W2080883955 cites W2118846428 @default.
• W2080883955 cites W2172225485 @default.
• W2080883955 doi "https://doi.org/10.1016/0014-2999(90)90402-r" @default.
• W2080883955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2163851" @default.
• W2080883955 hasPublicationYear "1990" @default.
• W2080883955 type Work @default.
• W2080883955 sameAs 2080883955 @default.
• W2080883955 citedByCount "33" @default.
• W2080883955 countsByYear W20808839552012 @default.
• W2080883955 countsByYear W20808839552014 @default.
• W2080883955 countsByYear W20808839552016 @default.
• W2080883955 countsByYear W20808839552018 @default.
• W2080883955 crossrefType "journal-article" @default.
• W2080883955 hasAuthorship W2080883955A5019499764 @default.
• W2080883955 hasAuthorship W2080883955A5020116197 @default.
• W2080883955 hasAuthorship W2080883955A5022326769 @default.
• W2080883955 hasAuthorship W2080883955A5027713819 @default.
• W2080883955 hasAuthorship W2080883955A5036202603 @default.
• W2080883955 hasAuthorship W2080883955A5038230315 @default.
• W2080883955 hasAuthorship W2080883955A5039382619 @default.
• W2080883955 hasAuthorship W2080883955A5044543101 @default.
• W2080883955 hasAuthorship W2080883955A5045398922 @default.
• W2080883955 hasAuthorship W2080883955A5055492584 @default.
• W2080883955 hasAuthorship W2080883955A5072966767 @default.
• W2080883955 hasConcept C126322002 @default.
• W2080883955 hasConcept C134018914 @default.
• W2080883955 hasConcept C150903083 @default.
• W2080883955 hasConcept C16613235 @default.
• W2080883955 hasConcept C170493617 @default.
• W2080883955 hasConcept C185592680 @default.
• W2080883955 hasConcept C202751555 @default.
• W2080883955 hasConcept C207001950 @default.
• W2080883955 hasConcept C2776980637 @default.
• W2080883955 hasConcept C2777803847 @default.
• W2080883955 hasConcept C2780091579 @default.
• W2080883955 hasConcept C2780919550 @default.
• W2080883955 hasConcept C2781063702 @default.
• W2080883955 hasConcept C2781372283 @default.
• W2080883955 hasConcept C55493867 @default.
• W2080883955 hasConcept C57992300 @default.
• W2080883955 hasConcept C71924100 @default.
• W2080883955 hasConcept C86803240 @default.
• W2080883955 hasConcept C98274493 @default.
• W2080883955 hasConceptScore W2080883955C126322002 @default.
• W2080883955 hasConceptScore W2080883955C134018914 @default.
• W2080883955 hasConceptScore W2080883955C150903083 @default.
• W2080883955 hasConceptScore W2080883955C16613235 @default.
• W2080883955 hasConceptScore W2080883955C170493617 @default.
• W2080883955 hasConceptScore W2080883955C185592680 @default.
• W2080883955 hasConceptScore W2080883955C202751555 @default.
• W2080883955 hasConceptScore W2080883955C207001950 @default.
• W2080883955 hasConceptScore W2080883955C2776980637 @default.
• W2080883955 hasConceptScore W2080883955C2777803847 @default.
• W2080883955 hasConceptScore W2080883955C2780091579 @default.
• W2080883955 hasConceptScore W2080883955C2780919550 @default.
• W2080883955 hasConceptScore W2080883955C2781063702 @default.
• W2080883955 hasConceptScore W2080883955C2781372283 @default.
• W2080883955 hasConceptScore W2080883955C55493867 @default.
• W2080883955 hasConceptScore W2080883955C57992300 @default.
• W2080883955 hasConceptScore W2080883955C71924100 @default.
• W2080883955 hasConceptScore W2080883955C86803240 @default.
• W2080883955 hasConceptScore W2080883955C98274493 @default.
• W2080883955 hasIssue "1-2" @default.

• next