FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080885537> ?p ?o ?g. }

• W2080885537 endingPage "156" @default.
• W2080885537 startingPage "140" @default.
• W2080885537 abstract "To identify early changes in protein expression associated with cisplatin ototoxicity, we used two dimensional-difference gel electrophoresis (2D-DIGE) and matrix-assisted laser desorption-time-of-flight (MALDI-TOF) mass spectrometry to analyze proteins from P3 rat cochleae that were cultured for 3 h with or without 1 mM cisplatin. Replicate analysis of fluorescent images from six gels revealed significant (p < 0.01) cisplatin-induced changes (greater than 1.5-fold) in expression of 22 cochlear proteins. These include increases in the expression of five proteins, four of which were identified as nucleobindin 1, a nuclear calcium signaling and homeostasis protein (2.1-fold), heterogeneous nuclear ribonucleoprotein C, an RNA processing protein (1.8-fold), a 55 kDa protein that is either endothelial differentiation-related factor 1 or alpha-6 tubulin (1.7-fold), and calreticulin, a calcium binding chaperone of the endoplasmic reticulum (ER, 1.6-fold). The expression of 17 proteins was significantly (p < 0.01) decreased by greater than 1.5-fold. These include ribonuclease/angiogenin inhibitor 1 (1.6-fold), RAS-like, family 12 (predicted), ras association (RalGDS/AF-6) domain family 5 (4.5-fold), homologous the RAS family of GTPase signaling proteins (2.4-fold), and Protein tyrosine phosphatase domain containing 1 (predicted, 6.1-fold). We identified seven cochlear proteins with either smaller (1.2–1.5-fold) or less significant (p < 0.05) cisplatin-induced changes in expression. Notably, heat shock 70 kDa protein 5 (Hspa5, Grp78, and BiP), an ER chaperone protein involved in stress response, decreased 1.7-fold. We observed changes consistent with phosphorylation in the level of isoforms of another ER stress-induced protein, glucose-regulated protein Grp58. Changes in cisplatin-induced protein expression are discussed with respect to known or hypothesized functions of the identified proteins." @default.
• W2080885537 created "2016-06-24" @default.
• W2080885537 creator A5006852480 @default.
• W2080885537 creator A5007875211 @default.
• W2080885537 creator A5046283555 @default.
• W2080885537 creator A5050734751 @default.
• W2080885537 creator A5051138582 @default.
• W2080885537 creator A5061966364 @default.
• W2080885537 creator A5082893751 @default.
• W2080885537 date "2007-04-01" @default.
• W2080885537 modified "2023-09-26" @default.
• W2080885537 title "Proteomic analysis of cisplatin-induced cochlear damage: Methods and early changes in protein expression" @default.
• W2080885537 cites W1500591362 @default.
• W2080885537 cites W1785329267 @default.
• W2080885537 cites W1963794097 @default.
• W2080885537 cites W1964443249 @default.
• W2080885537 cites W1967215636 @default.
• W2080885537 cites W1970567936 @default.
• W2080885537 cites W1971977620 @default.
• W2080885537 cites W1972272880 @default.
• W2080885537 cites W1979608508 @default.
• W2080885537 cites W1987230919 @default.
• W2080885537 cites W1988206911 @default.
• W2080885537 cites W1992315035 @default.
• W2080885537 cites W1994767237 @default.
• W2080885537 cites W1999203392 @default.
• W2080885537 cites W1999771431 @default.
• W2080885537 cites W2000504232 @default.
• W2080885537 cites W2001252293 @default.
• W2080885537 cites W2001742245 @default.
• W2080885537 cites W2003717217 @default.
• W2080885537 cites W2006290814 @default.
• W2080885537 cites W2009289333 @default.
• W2080885537 cites W2017205324 @default.
• W2080885537 cites W2018833058 @default.
• W2080885537 cites W2024528936 @default.
• W2080885537 cites W2033761125 @default.
• W2080885537 cites W2035041597 @default.
• W2080885537 cites W2035826838 @default.
• W2080885537 cites W2035960655 @default.
• W2080885537 cites W2038305733 @default.
• W2080885537 cites W2039810057 @default.
• W2080885537 cites W2041368528 @default.
• W2080885537 cites W2045891434 @default.
• W2080885537 cites W2047714133 @default.
• W2080885537 cites W2047795320 @default.
• W2080885537 cites W2051330637 @default.
• W2080885537 cites W2053540177 @default.
• W2080885537 cites W2055063265 @default.
• W2080885537 cites W2068923731 @default.
• W2080885537 cites W2071371511 @default.
• W2080885537 cites W2073945352 @default.
• W2080885537 cites W2076391844 @default.
• W2080885537 cites W2077260366 @default.
• W2080885537 cites W2079746230 @default.
• W2080885537 cites W2079796760 @default.
• W2080885537 cites W2081178915 @default.
• W2080885537 cites W2092680193 @default.
• W2080885537 cites W2097040991 @default.
• W2080885537 cites W2097254828 @default.
• W2080885537 cites W2099252920 @default.
• W2080885537 cites W2102084759 @default.
• W2080885537 cites W2105542363 @default.
• W2080885537 cites W2107601804 @default.
• W2080885537 cites W2109936231 @default.
• W2080885537 cites W2112025493 @default.
• W2080885537 cites W2122987235 @default.
• W2080885537 cites W2128972757 @default.
• W2080885537 cites W2130852318 @default.
• W2080885537 cites W2142000697 @default.
• W2080885537 cites W2143930939 @default.
• W2080885537 cites W2152959391 @default.
• W2080885537 cites W2159590215 @default.
• W2080885537 cites W2164277862 @default.
• W2080885537 cites W2164460491 @default.
• W2080885537 cites W2167740893 @default.
• W2080885537 cites W2168683474 @default.
• W2080885537 cites W2168846709 @default.
• W2080885537 cites W2616085479 @default.
• W2080885537 cites W4250131710 @default.
• W2080885537 doi "https://doi.org/10.1016/j.heares.2006.12.017" @default.
• W2080885537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17321087" @default.
• W2080885537 hasPublicationYear "2007" @default.
• W2080885537 type Work @default.
• W2080885537 sameAs 2080885537 @default.
• W2080885537 citedByCount "43" @default.
• W2080885537 countsByYear W20808855372012 @default.
• W2080885537 countsByYear W20808855372013 @default.
• W2080885537 countsByYear W20808855372014 @default.
• W2080885537 countsByYear W20808855372015 @default.
• W2080885537 countsByYear W20808855372016 @default.
• W2080885537 countsByYear W20808855372017 @default.
• W2080885537 countsByYear W20808855372018 @default.
• W2080885537 countsByYear W20808855372022 @default.
• W2080885537 crossrefType "journal-article" @default.
• W2080885537 hasAuthorship W2080885537A5006852480 @default.
• W2080885537 hasAuthorship W2080885537A5007875211 @default.
• W2080885537 hasAuthorship W2080885537A5046283555 @default.

• next