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- W2080885719 abstract "The aim of this study was to determine the serum markers that predict significant inflammation in patients with chronic hepatitis B (CHB).Between October 2005 and June 2009, 384 subjects with CHB were enrolled.Multiple logistic regression analysis identified the ALT, hyaluronic acid (HA) and procollagen III N-terminal peptide (PIIINP) as independent predictors of significant inflammation (grade≥3). We constructed a formula for predicting significant inflammation. A significant inflammation (SI) score=1.773×ALT score+1.599×PIIINP score+0.677×HA score-1.962. The area under receiver operating characteristic curve of the SI score was 0.831. The sensitivity, specificity, positive predictive value and negative predictive value of the SI score were 79.5%, 70.8%, 76.8% and 74.3%, respectively.A simple scoring system including ALT, PIIINP and HA is an accurate non-invasive predictor of significant inflammatory activities in patients with CHB." @default.
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- W2080885719 date "2012-12-01" @default.
- W2080885719 modified "2023-09-26" @default.
- W2080885719 title "Serum markers for predicting significant necroinflammatory activity in patients with chronic hepatitis B" @default.
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- W2080885719 doi "https://doi.org/10.1016/j.clinbiochem.2012.07.107" @default.
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